Wiklund L, Sahlin K
Crit Care Med. 1985 Feb;13(2):109-13. doi: 10.1097/00003246-198502000-00012.
Metabolic acidosis was induced in 18 piglets of Swedish native breed by prolonged iv infusion of lactic acid, which decreased both blood and muscle pH. A two- to three-fold increase in muscle lactate content was related to the decrease in muscle pH. Treatment of the induced metabolic acidosis with either sodium bicarbonate or a tris buffer mixture re-established normal or near-normal arterial pH, but PaCO2 remained elevated after sodium bicarbonate infusion. The pH in muscle and cerebrospinal fluid (CSF) normalized only in the group treated with the tris buffer mixture. Thus, the tris buffer mixture was more effective than traditional sodium bicarbonate in correcting the acid-base disturbance in the CSF and the muscle intracellular compartment.
通过长时间静脉输注乳酸，在18头瑞典本地品种仔猪中诱发代谢性酸中毒，这降低了血液和肌肉的pH值。肌肉乳酸含量增加两到三倍与肌肉pH值降低有关。用碳酸氢钠或三羟甲基氨基甲烷缓冲液混合物治疗诱发的代谢性酸中毒可使动脉pH值恢复正常或接近正常，但输注碳酸氢钠后动脉血二氧化碳分压（PaCO2）仍升高。仅在使用三羟甲基氨基甲烷缓冲液混合物治疗的组中，肌肉和脑脊液（CSF）的pH值恢复正常。因此，在纠正脑脊液和肌肉细胞内区室的酸碱紊乱方面，三羟甲基氨基甲烷缓冲液混合物比传统的碳酸氢钠更有效。
