Gonzalez N C, Kelling E C, Strome D R, Clancy R L
Respir Physiol. 1976 Feb;26(1):1-10. doi: 10.1016/0034-5687(76)90047-5.
Nephrectomized, open chested dogs were infused with 25-30 ml.kg(-1) body weight of 0.15 M NaCl (group I), 0.15 MHCl (Group II) or 0.3 M lactic acid (Group) III). Pulmonary ventilation was maintained constant in the three groups. Intracellular pH was calculated with the CO2 method. No significant intracellular or extracellular acid-base changes were produced in Group I. A similar degree of extracellular acidosis was achieved in Groups II and III. In spite of constant arterial PCO2, the PCO2 of mixed, coronary sinus and femoral vanous blood increased moderately after the infusion in Groups II and III. It was calculated that less than half of the HCl acid infused remained in the extracellular space. However, no significant changes were observed in the acid-base composition of skeletal muscle in either Group II or III. Comparison of the cardiac muscle cell acid-base composition of Group I with that of Groups II and III whows that metabolic acidosis of the degree and duration produced in these experiments does not produce appreciable myocardial acidosis.
对肾切除且开胸的狗输注25 - 30毫升/千克体重的0.15M氯化钠（第一组）、0.15M盐酸（第二组）或0.3M乳酸（第三组）。三组的肺通气保持恒定。采用二氧化碳法计算细胞内pH值。第一组未产生明显的细胞内或细胞外酸碱变化。第二组和第三组实现了相似程度的细胞外酸中毒。尽管动脉血二氧化碳分压恒定，但第二组和第三组输注后混合静脉血、冠状窦血和股静脉血的二氧化碳分压适度升高。据计算，输注的盐酸中不到一半留在细胞外空间。然而，第二组和第三组骨骼肌的酸碱组成均未观察到明显变化。将第一组心肌细胞的酸碱组成与第二组和第三组进行比较表明，这些实验中产生的程度和持续时间的代谢性酸中毒不会导致明显的心肌酸中毒。
