Grass Center for Bioengineering, The Hebrew University of Jerusalem, Jerusalem, Israel.
Believer Meats, Rehovot, Israel.
Nat Food. 2024 Aug;5(8):693-702. doi: 10.1038/s43016-024-01022-w. Epub 2024 Aug 21.
Cellular agriculture aims to meet the growing demand for animal products. However, current production technologies result in low yields, leading to economic projections that prohibit cultivated meat scalability. Here we use tangential flow filtration for continuous manufacturing of cultivated meat to produce biomass of up to 130 × 10 cells per ml, corresponding to yields of 43% w/v and multiple harvests for over 20 days. Continuous manufacturing was carried out in an animal-component-free culture medium for US$0.63 l that supports the long-term, high density culture of chicken cells. Using this empirical data, we conducted a techno-economic analysis for a theoretical production facility of 50,000 l, showing that the cost of cultivated chicken can drop to within the range of organic chicken at US$6.2 lb by using perfusion technology. Whereas other variables would also affect actual market prices, continuous manufacturing can offer cost reductions for scaling up cultivated meat production.
细胞农业旨在满足对动物产品日益增长的需求。然而，目前的生产技术导致产量低，经济预测禁止了培养肉的可扩展性。在这里，我们使用切向流过滤进行连续制造培养肉，以生产高达每毫升 130×10 个细胞的生物质，相当于 43%（w/v）的产率和超过 20 天的多次收获。连续制造是在无动物成分的培养基中进行的，每升成本为 0.63 美元，可支持鸡细胞的长期、高密度培养。使用这些经验数据，我们对一个 50000 升的理论生产设施进行了技术经济分析，结果表明，通过使用灌注技术，培养鸡肉的成本可以降低到每磅 6.2 美元，达到有机鸡肉的范围。虽然其他变量也会影响实际市场价格，但连续制造可以为培养肉生产的规模化提供成本降低。
