School of Public Health, Jining Medical University, Jining, 272067, Shandong, China.
Department of Dermatology, Jining No.1 People's Hospital, Jining, 272067, Shandong, China.
Sci Rep. 2024 Aug 24;14(1):19683. doi: 10.1038/s41598-024-70707-w.
This study aims to illustrate epidemiology of comorbid CVD in the real-world clinical setting of patients with psoriasis in China. We used data of adult patients with psoriasis who were registered in the register of China National Clinical Center for Skin and Immune Diseases between August 2020 and September 2021. Psoriasis was clinically diagnosed following the national guidelines. Univariate and multivariate logistic regression models were used to examine the factors associated with comorbid CVD in patients with psoriasis. Of the 11,560 psoriasis patients (age ≥ 18 years, mean age 41.87 years, 64.88% males), 236 were ascertained with CVD, with the overall prevalence being 2.62%. Multivariate logistic regression analysis suggested that the odds ratio (95% confidence interval) of CVD in psoriasis patients was 2.27 (2.03-2.54) for older age (per 10-year increment), 0.65 (0.48-0.90) for female, 2.07 (1.39-3.06) for obesity (BMI ≥ 28 vs. < 24 kg/m), 2.55 (1.85-2.52) for smoking, 7.63 (5.86-9.94) for hypertension, 4.27 (3.76-4.85) for diabetes, 1.14 (1.00-1.30) for having a history of drug allergy, 2.27 (1.61-3.20) for having family history of psoriasis, and 1.76 (1.16-2.67) for severe disease (severe vs. mild) with a dose-response relationship (P < 0.001). In patients with psoriasis, comorbid CVD was associated with smoking, obesity, hypertension, diabetes, history of drug allergy, family history of psoriasis, and the psoriasis severity.
本研究旨在阐明中国真实临床环境中银屑病患者合并 CVD 的流行病学情况。我们使用了 2020 年 8 月至 2021 年 9 月期间在中国国家皮肤与免疫疾病临床医学研究中心注册的成年银屑病患者的数据。银屑病的临床诊断符合国家指南。采用单因素和多因素 logistic 回归模型来检验银屑病患者合并 CVD 的相关因素。在 11560 例（年龄≥18 岁，平均年龄 41.87 岁，64.88%为男性）银屑病患者中，有 236 例患者被确诊为 CVD，总体患病率为 2.62%。多因素 logistic 回归分析表明，银屑病患者 CVD 的优势比（95%置信区间）为：年龄每增加 10 岁（2.27[2.03-2.54]）、女性（0.65[0.48-0.90]）、肥胖（BMI≥28 与<24 kg/m2）（2.07[1.39-3.06]）、吸烟（2.55[1.85-2.52]）、高血压（7.63[5.86-9.94]）、糖尿病（4.27[3.76-4.85]）、药物过敏史（1.14[1.00-1.30]）、银屑病家族史（2.27[1.61-3.20]）和严重疾病（重度与轻度）（1.76[1.16-2.67]）与剂量反应关系（P<0.001）。在银屑病患者中，合并 CVD 与吸烟、肥胖、高血压、糖尿病、药物过敏史、银屑病家族史和疾病严重程度相关。
