Zhong Geng, Liu Qingzhou, Wang Qiyu, Qiu Haoji, Li Hanlin, Xu Tailin
School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518060, PR China.
Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen, 518060, PR China.
Biosens Bioelectron. 2024 Dec 1;265:116697. doi: 10.1016/j.bios.2024.116697. Epub 2024 Aug 22.
Fitness monitoring has become increasingly important in modern lifestyles; the current fitness monitoring always relies on physical sensors, making it challenging to detect pertinent issues at a deeper level when exercising. Here, we report a fully integrated wearable microneedle sensor that simultaneously measures fitness related biomarkers (e.g., glucose, lactate, and alcohol) during physical exercise. Such a sensor integrates a biocompatible 3D-printed microneedle array that can comfortably access skin interstitial fluid and a small circuit for signal processing and calibration, and wireless communication. The microneedle array features good biocompatibility and highly sensitive biochemical sensors that can detect even the slightest variations within the biomarkers of this fluid. On-body experimental results indicate that such a sensor can monitor fitness-related biomarkers across multiple subjects and support multi-day monitoring, with results showing a good correlation with commercial devices. The data was transmitted to a smartphone via Bluetooth and uploaded to cloud platforms for further health assessment. This study has the potential to boost intelligent wearable devices in sports health.
在现代生活方式中，健康监测变得越来越重要；当前的健康监测总是依赖于物理传感器，这使得在运动时更深入地检测相关问题具有挑战性。在此，我们报告了一种完全集成的可穿戴微针传感器，它能在体育锻炼期间同时测量与健康相关的生物标志物（如葡萄糖、乳酸和酒精）。这种传感器集成了一个生物相容性3D打印微针阵列，它可以舒适地获取皮肤间质液，以及一个用于信号处理、校准和无线通信的小型电路。微针阵列具有良好的生物相容性和高度灵敏的生化传感器，甚至可以检测出这种液体生物标志物内最微小的变化。人体实验结果表明，这种传感器可以跨多个受试者监测与健康相关的生物标志物，并支持多天监测，结果显示与商业设备具有良好的相关性。数据通过蓝牙传输到智能手机，并上传到云平台进行进一步的健康评估。这项研究有潜力推动运动健康领域的智能可穿戴设备发展。
