前B细胞系中免疫球蛋白重链基因座的高突变
Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.
作者信息
Wabl M, Burrows P D, von Gabain A, Steinberg C
出版信息
Proc Natl Acad Sci U S A. 1985 Jan;82(2):479-82. doi: 10.1073/pnas.82.2.479.
Abstract
Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the immunoglobulin heavy chain locus. Only one allele is "active"; the other, "silent" allele contains an amber termination codon. The rate of reversion of this amber codon was determined to be 0.3-1 X 10(-4) per cell generation. This high rate is termed hypermutation.
摘要
在著名的前B淋巴细胞系18 - 81中，大多数细胞在免疫球蛋白重链基因座上两个等位基因的基因都已正确组装。只有一个等位基因是“活跃的”；另一个“沉默”等位基因含有一个琥珀色终止密码子。已确定该琥珀色密码子的回复突变率为每细胞世代0.3 - 1×10⁻⁴。这种高突变率被称为超突变。
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