Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Oslo, Norway.
J Extracell Vesicles. 2024 Aug;13(8):e12500. doi: 10.1002/jev2.12500.
The benefits of regular physical exercise on cancer prevention, as well as reducing fatigue, treatment side effects and recurrence, and improving quality of life and overall survival of cancer patients, are increasingly recognised. Initial studies showed that the concentration of extracellular vesicles (EVs) increases during physical activity and that EVs carry biologically active cargo. These EVs are released by blood cells, skeletal muscle and other organs involved in exercise, thus suggesting that EVs may mediate tissue crosstalk during exercise. This possibility triggered a great interest in the study of the roles of EVs in systemic adaptation to exercise and in their potential applications in the prevention and treatment of various diseases, including cancer. This review presents studies exploring the concentration and molecular cargo of EVs released during exercise. Furthermore, we discuss putative stimuli that may trigger EV release from various cell types, the biological functions and the impact of exercise-induced EVs on cancer development and progression. Understanding the interplay between exercise, EVs, and cancer biology may offer insights into novel therapeutic strategies and preventive measures for cancer.
定期进行体育锻炼对预防癌症、减轻疲劳、治疗副作用和复发、提高癌症患者的生活质量和总体生存率的益处，正日益得到认可。最初的研究表明，细胞外囊泡（EVs）的浓度在体育活动中增加，并且 EVs 携带具有生物活性的货物。这些 EVs 是由血细胞、骨骼肌和其他参与运动的器官释放的，这表明 EVs 可能在运动过程中介导组织间的交流。这种可能性引发了人们对 EVs 在运动引起的全身适应及其在预防和治疗各种疾病（包括癌症）中的潜在应用中的作用的极大兴趣。这篇综述介绍了研究 EVs 在运动过程中释放的浓度和分子货物的研究。此外，我们还讨论了可能触发各种细胞类型释放 EV 的刺激因素、生物学功能以及运动诱导的 EVs 对癌症发展和进展的影响。了解运动、EVs 和癌症生物学之间的相互作用可能为癌症的治疗策略和预防措施提供新的见解。
