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牛高致病性禽流感病毒在乳副产品乳糖中的稳定性及灭活情况

Bovine highly pathogenic avian influenza virus stability and inactivation in the milk byproduct lactose.

作者信息

Kwon Taeyong, Gebhardt Jordan T, Lyoo Eu Lim, Nooruzzaman Mohammed, Gaudreault Natasha N, Morozov Igor, Diel Diego G, Richt Juergen A

机构信息

Kansas State University, Manhattan, Kansas, USA.

Cornell University, Ithaca, New York, USA.

出版信息

bioRxiv. 2024 Aug 12:2024.08.12.607665. doi: 10.1101/2024.08.12.607665.

DOI:10.1101/2024.08.12.607665
PMID:39185164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11343113/
Abstract

A bovine isolate of highly pathogenic avian influenza H5N1 virus was stable for 14 days in a concentrated lactose solution at under refrigerated conditions. Heat or citric acid treatments successfully inactivated viruses in lactose. This study highlights the persistence of HPAIV in lactose and its efficient inactivation under industrial standards.

摘要

一种高致病性禽流感H5N1病毒的牛源分离株在冷藏条件下于浓缩乳糖溶液中可稳定存在14天。加热或柠檬酸处理可成功使乳糖中的病毒失活。本研究强调了高致病性禽流感病毒在乳糖中的持久性及其在工业标准下的有效灭活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e125/11343113/e1f2164028e0/nihpp-2024.08.12.607665v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e125/11343113/e1f2164028e0/nihpp-2024.08.12.607665v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e125/11343113/e1f2164028e0/nihpp-2024.08.12.607665v1-f0001.jpg

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本文引用的文献

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Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle in the United States.美国奶牛中高致病性甲型禽流感（H5N1）的出现及跨州传播
Science. 2025 Apr 25;388(6745):eadq0900. doi: 10.1126/science.adq0900.
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Spillover of highly pathogenic avian influenza H5N1 virus to dairy cattle.高致病性禽流感 H5N1 病毒向奶牛的溢出。
Nature. 2024 Oct;634(8034):669-676. doi: 10.1038/s41586-024-07849-4. Epub 2024 Jul 25.
3
Detection and characterization of H5N1 HPAIV in environmental samples from a dairy farm.
从一个奶牛场的环境样本中检测和分析 H5N1 高致病性禽流感病毒。
Virus Genes. 2024 Oct;60(5):517-527. doi: 10.1007/s11262-024-02085-4. Epub 2024 Jul 15.
4
Characterization of highly pathogenic avian influenza virus in retail dairy products in the US.美国零售乳制品中高致病性禽流感病毒的特征。
J Virol. 2024 Jul 23;98(7):e0088124. doi: 10.1128/jvi.00881-24. Epub 2024 Jul 3.
5
Inactivation of Avian Influenza A(H5N1) Virus in Raw Milk at 63°C and 72°C.63°C和72°C条件下生乳中甲型禽流感病毒（H5N1）的灭活
N Engl J Med. 2024 Jul 4;391(1):90-92. doi: 10.1056/NEJMc2405488. Epub 2024 Jun 14.
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Cow's Milk Containing Avian Influenza A(H5N1) Virus - Heat Inactivation and Infectivity in Mice.含甲型禽流感病毒（H5N1）的牛奶——热灭活及对小鼠的感染性
N Engl J Med. 2024 Jul 4;391(1):87-90. doi: 10.1056/NEJMc2405495. Epub 2024 May 24.
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Highly Pathogenic Avian Influenza A(H5N1) Virus Infection in a Dairy Farm Worker.一名奶农感染高致病性甲型禽流感（H5N1）病毒
N Engl J Med. 2024 Jun 6;390(21):2028-2029. doi: 10.1056/NEJMc2405371. Epub 2024 May 3.
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Avian influenza overview April - June 2023.2023年4月至6月禽流感概述
EFSA J. 2023 Jul 20;21(7):e08191. doi: 10.2903/j.efsa.2023.8191. eCollection 2023 Jul.