Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Viruses. 2024 Sep 12;16(9):1451. doi: 10.3390/v16091451.
The recent incursion of highly pathogenic influenza viruses into dairy cattle opens new insights for influenza virus ecology and its interspecies transmission and may have a significant impact on public health and agriculture. The aim of this study was to determine the stability of a bovine highly pathogenic avian influenza H5N1 virus isolate in the milk byproduct lactose and to evaluate two inactivation methods using industrial procedures. The bovine isolate of the highly pathogenic avian influenza H5N1 virus was stable for 14 days in a concentrated lactose solution under refrigerated conditions. Heat or citric acid treatments successfully inactivated the virus in lactose. This study highlights the persistence of HPAIV in lactose and its efficient inactivation under industrial standards.
高致病性流感病毒最近侵入奶牛，为流感病毒生态学及其物种间传播提供了新的见解，可能对公共卫生和农业产生重大影响。本研究旨在确定高致病性禽流感 H5N1 病毒在牛奶副产品乳糖中的稳定性，并评估两种使用工业程序的灭活方法。在冷藏条件下，高致病性禽流感 H5N1 病毒的牛分离株在浓缩乳糖溶液中稳定 14 天。热处理或柠檬酸处理可成功使乳糖中的病毒失活。本研究强调了 HPAIV 在乳糖中的持久性及其在工业标准下的有效灭活。
