美国奶牛中高致病性甲型禽流感（H5N1）的出现及跨州传播
Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle in the United States.
作者信息
Nguyen Thao-Quyen, Hutter Carl R, Markin Alexey, Thomas Megan, Lantz Kristina, Killian Mary Lea, Janzen Garrett M, Vijendran Sriram, Wagle Sanket, Inderski Blake, Magstadt Drew R, Li Ganwu, Diel Diego G, Frye Elisha Anna, Dimitrov Kiril M, Swinford Amy K, Thompson Alexis C, Snekvik Kevin R, Suarez David L, Lakin Steven M, Schwabenlander Stacey, Ahola Sara C, Johnson Kammy R, Baker Amy L, Robbe-Austerman Suelee, Torchetti Mia Kim, Anderson Tavis K
机构信息
Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, USA.
Department of Computer Science, Iowa State University, Ames, IA, USA.
出版信息
Science. 2025 Apr 25;388(6745):eadq0900. doi: 10.1126/science.adq0900.
Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) viruses related to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected wild birds, poultry, and mammals. Our genomic analysis and epidemiological investigation showed that a reassortment event in wild bird populations preceded a single wild bird-to-cattle transmission episode. The movement of asymptomatic or presymptomatic cattle has likely played a role in the spread of HPAI within the United States dairy herd. Some molecular markers that may lead to changes in transmission efficiency and phenotype were detected at low frequencies. Continued transmission of H5N1 HPAI within dairy cattle increases the risk for infection and subsequent spread of the virus to human populations.
高致病性禽流感（HPAI）病毒跨越物种屏障，有可能引发大流行。在北美，与鹅/广东2.3.4.4b血凝素系统发育分支相关的HPAI A(H5N1)病毒已感染野生鸟类、家禽和哺乳动物。我们的基因组分析和流行病学调查表明，野生鸟类群体中的一次重配事件先于一次野生鸟类到牛的单一传播事件。无症状或症状前期牛的移动可能在美国奶牛群中HPAI的传播中发挥了作用。在低频下检测到了一些可能导致传播效率和表型变化的分子标记。H5N1 HPAI在奶牛中持续传播增加了病毒感染人类并随后传播的风险。
Zotero 插件