Dahake Prasanna T, Joshi Sphurti S, Kale Yogesh J, Dadpe Mahesh V, Kendre Shrikant B
Department of Pediatrics and Preventive Dentistry, Maharashtra Institute of Dental Sciences & Research (MIDSR), Latur, Maharashtra, India.
Int J Clin Pediatr Dent. 2024 Apr;17(Suppl 1):S11-S16. doi: 10.5005/jp-journals-10005-2788.
Evaluating the antimicrobial efficacy of the novel combinations of zinc oxide mixed with ajwain oil (ZNOA) and combination of ajwain and eugenol (ZNOAE) vs conventionally used zinc oxide eugenol (ZNOE) against endodontic pathogens like and .
The pure cultures of (MTCC 443) and (MTCC 439) were revived and grown on selective cultural media. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the test materials were determined correspondingly through sequential dilution and agar well diffusion methods, as per Clinical and Laboratory Standard Institute (CLSI) guidelines. The data values were presented as mean ± standard deviation (SD). The comparisons among groups were completed through the one-way analysis of variance (ANOVA) test, whereas intragroup pairwise comparisons were completed using the unpaired -test ( < 0.05).
Minimum inhibitory concentration values against and of ZNOE were 250 and 500 µg/mL, ZNOA was 250 µg/mL, and ZNOAE were 125 and 250 µg/mL, correspondingly. MBC values in the form of inhibition zone against by ZNOE were 21.33 ± 1.53 mm, ZNOA 18.67 ± 1.53 mm, and ZNOAE 20.33 ± 1.53 mm. The inhibition zone for ZNOE was 14.33 ± 2.08 mm, ZNOA 18.67 ± 2.08 mm, and ZNOAE 24.33 ± 1.53 mm.
All test materials demonstrated good antibacterial efficacy. However, between the novel combinations of test materials, ZNOA showed better antimicrobial efficacy against resistant endodontic pathogens than ZNOE.
Dahake PT, Joshi SS, Kale YJ, A Novel Combination of Zinc Oxide with Two Essential Oils Exerts Antimicrobial Effect against Endodontic Pathogens . Int J Clin Pediatr Dent 2024;17(S-1):S11-S16.
评估氧化锌与阿育吠陀油混合的新型组合（ZNOA）以及阿育吠陀与丁香酚组合（ZNOAE）相对于传统使用的氧化锌丁香酚（ZNOE）对牙髓病原体如[具体病原体1]和[具体病原体2]的抗菌效果。
复苏[具体病原体1]（MTCC 443）和[具体病原体2]（MTCC 439）的纯培养物，并在选择性培养基上培养。根据临床和实验室标准协会（CLSI）指南，通过连续稀释和琼脂孔扩散法相应地测定测试材料的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。数据值以平均值±标准差（SD）表示。组间比较通过单因素方差分析（ANOVA）检验完成，而组内成对比较使用不成对t检验（P < 0.05）。
ZNOE对[具体病原体1]和[具体病原体2]的最低抑菌浓度值分别为250和500μg/mL，ZNOA为250μg/mL，ZNOAE分别为125和250μg/mL。ZNOE对[具体病原体1]的以抑菌圈形式表示的MBC值为21.33±1.53mm，ZNOA为18.67±1.53mm，ZNOAE为20.33±1.53mm。ZNOE对[具体病原体2]的抑菌圈为14.33±2.08mm，ZNOA为18.67±2.08mm，ZNOAE为24.33±1.53mm。
所有测试材料均显示出良好的抗菌效果。然而，在测试材料的新型组合中，ZNOA对耐药牙髓病原体的抗菌效果优于ZNOE。
达哈克PT，乔希SS，卡莱YJ，《氧化锌与两种精油的新型组合对牙髓病原体具有抗菌作用》。《国际临床儿科牙科杂志》2024；17（S - 1）：S11 - S
