病毒和细胞微小RNA作为病毒发病机制和免疫的决定因素。
Viral and cellular microRNAs as determinants of viral pathogenesis and immunity.
作者信息
Gottwein Eva, Cullen Bryan R
机构信息
Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Cell Host Microbe. 2008 Jun 12;3(6):375-87. doi: 10.1016/j.chom.2008.05.002.
Abstract
MicroRNAs (miRNAs) have recently emerged as key posttranscriptional regulators of gene expression in multicellular eukaryotes. It is increasingly clear that miRNAs of both viral and cellular origin can positively or negatively influence viral replication. Viral miRNAs can directly alter host physiology, including components of the immune system, and host miRNAs can directly alter the virus life cycle. Here, we discuss what is known about how viral and cellular miRNAs influence viral replication and pathogenic potential through their regulation of viral mRNAs or by reshaping cellular gene expression.
摘要
微小RNA（miRNA）最近已成为多细胞真核生物中基因表达的关键转录后调节因子。越来越清楚的是，病毒源性和细胞源性的miRNA均可对病毒复制产生正向或负向影响。病毒miRNA可直接改变宿主生理，包括免疫系统的组成部分，而宿主miRNA可直接改变病毒生命周期。在此，我们讨论关于病毒和细胞miRNA如何通过调节病毒mRNA或重塑细胞基因表达来影响病毒复制和致病潜力的已知情况。
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