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微创二尖瓣和三尖瓣联合手术同期行手术消融的长期疗效

Long-term outcomes of minimally invasive concomitant mitral and tricuspid valve surgery with surgical ablation.

作者信息

Yoon Sungsil, Kim Kitae, Yoo Jae Suk, Kim Joon Bum, Chung Cheol Hyun, Jung Sung-Ho

机构信息

Department of Thoracic and Cardiovascular Surgery, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea.

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

Interdiscip Cardiovasc Thorac Surg. 2024 Sep 4;39(3). doi: 10.1093/icvts/ivae146.

Abstract

OBJECTIVES

We compared the outcomes of a right mini-thoracotomy (RMT) versus those of a sternotomy for concomitant mitral and tricuspid valve surgery and surgical ablation.

METHODS

We analysed patients who underwent concomitant mitral and tricuspid valve surgery and surgical ablation at a single institution (mean follow-up: 7 years) after propensity score matching. The primary and secondary outcomes were all-cause death, composite major adverse events (including stroke, reoperation, readmission, permanent pacemaker insertion) and recurrence of atrial fibrillation (A-fib). A subgroup analysis was performed.

RESULTS

A total of 797 procedures (mean age: 61.6 years; RMT: 45.2%; female: 66.5%; mitral valve repair: 33.6%) were done; 267 pairs were matched. The 5- and 10-year overall survival in the matched cohort was 92.7% and 86.9% for the RMT group and 92.1% and 83.1% for the sternotomy group (P = 0.879). Significant differences were not observed in major adverse events (P = 0.273; hazard ratio: 0.76) and A-fib recurrence (P = 0.080; hazard ratio: 0.72). The RMT group had lower rates of postoperative low cardiac output syndrome (P = 0.019) and acute renal failure (P = 0.003). Atrial fibrillation high-risk factors (including long-standing A-fib, enlarged left atrium, old age) exhibited significant interactions (P for interaction = 0.002) with the approach regarding A-fib recurrence.

CONCLUSIONS

In this study, an RMT exhibited no significant differences in long-term outcomes compared to a sternotomy, but it could remain a clinically reasonable option. Patients with a high risk of A-fib may have favourable ablation outcomes with a sternotomy.

摘要

目的

我们比较了右胸小切口(RMT)与胸骨切开术用于二尖瓣和三尖瓣联合手术及手术消融的效果。

方法

我们分析了在单一机构接受二尖瓣和三尖瓣联合手术及手术消融的患者(平均随访7年),这些患者经过了倾向评分匹配。主要和次要结局包括全因死亡、复合重大不良事件(包括中风、再次手术、再次入院、永久性起搏器植入)以及房颤复发。进行了亚组分析。

结果

共进行了797例手术(平均年龄:61.6岁;RMT:45.2%;女性:66.5%;二尖瓣修复:33.6%);匹配了267对。匹配队列中,RMT组5年和10年总生存率分别为92.7%和86.9%,胸骨切开术组分别为92.1%和83.1%(P = 0.879)。在重大不良事件(P = 0.273;风险比:0.76)和房颤复发方面(P = 0.080;风险比:0.72)未观察到显著差异。RMT组术后低心排血量综合征(P = 0.019)和急性肾衰竭(P = 0.003)的发生率较低。房颤高危因素(包括长期房颤、左心房扩大、老年)在房颤复发方面与手术方式存在显著交互作用(交互作用P值 = 0.002)。

结论

在本研究中,与胸骨切开术相比,RMT在长期结局方面无显著差异,但它仍可能是一种临床合理的选择。房颤高危患者采用胸骨切开术可能有较好的消融效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a013/11392673/88b286365461/ivae146f4.jpg

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