Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt.
Basic Science Department, Higher Institute of Applied Arts 5th Settlement, New Cairo, Egypt.
World J Microbiol Biotechnol. 2020 Jan 24;36(2):25. doi: 10.1007/s11274-020-2803-x.
In a search for novel therapeutic agents against pathogenic fungal species, Candida in addition to bacterial species, novel spinel nanoferrites were assayed against four pathogenic fungi isolated from different clinical samples of ear and skin infections: Aspergillus flavus, A. niger, A. terrus and A. fumigatus, four Candia species: Candida albicans, C. parapsilosis, C. krusei and C. tropicales, and four bacterial species: two Gram +ve: Bacillus subtilis and Streptococcus pyogenes, and two Gram -ve: Pseudomonas vulgaris and Escherichia coli. It was found that the assayed compounds displayed different levels of antifungal and antibacterial activities against all tested microorganisms. The antimicrobial potency depends on the method of synthesis of the nanoparticles and also on the microbial species.
在寻找针对致病真菌物种（除细菌外，还包括念珠菌）的新型治疗药物的过程中，我们对四种从耳部和皮肤感染的不同临床样本中分离出来的致病真菌（黄曲霉、黑曲霉、土曲霉和烟曲霉）、四种念珠菌（白色念珠菌、近平滑念珠菌、克柔念珠菌和热带念珠菌）和四种细菌（两种革兰氏阳性菌：枯草芽孢杆菌和化脓性链球菌，以及两种革兰氏阴性菌：普通变形杆菌和大肠杆菌）进行了新型尖晶石纳米铁氧体的抗真菌活性检测。结果发现，所检测的化合物对所有测试的微生物均显示出不同程度的抗真菌和抗菌活性。抗菌能力取决于纳米粒子的合成方法，也取决于微生物的种类。
