Ip C
Cancer Lett. 1985 Jan;25(3):325-31. doi: 10.1016/s0304-3835(15)30012-4.
The present study showed that in the dimethylbenz[a]anthracene-induced mammary tumor model in rats, the anticarcinogenic efficacy of selenium was much attenuated when the intake of vitamin E was deficient. Selenium supplementation at 2.5 mg/kg in the diet reduced the total tumor yield by 45% and 25%, respectively, in rats with an adequate or low vitamin E intake. Measurements of selected hepatic phase I and phase II detoxifying enzymes indicated that they were not responsive to changes in dietary vitamin E or selenium levels. However, a low vitamin E intake significantly increased lipid peroxidation in the mammary fat pad regardless of selenium status, suggesting that selenium supplementation was less effective under this nutritional condition and might be associated with the higher degree of oxidant stress in the cellular environment.
本研究表明，在二甲基苯并[a]蒽诱导的大鼠乳腺肿瘤模型中，当维生素E摄入不足时，硒的抗癌功效会大大减弱。在饮食中补充2.5mg/kg的硒，分别使维生素E摄入充足或低摄入的大鼠的肿瘤总发生率降低了45%和25%。对选定的肝脏I相和II相解毒酶的测量表明，它们对饮食中维生素E或硒水平的变化没有反应。然而，无论硒状态如何，低维生素E摄入都会显著增加乳腺脂肪垫中的脂质过氧化，这表明在这种营养状况下补充硒的效果较差，并且可能与细胞环境中较高程度的氧化应激有关。
