Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Aging Cell. 2024 Oct;23(10):e14296. doi: 10.1111/acel.14296. Epub 2024 Aug 26.
The hallmarks of aging have been influential in guiding the biology of aging research, with more recent and growing recognition of the interdependence of these hallmarks on age-related health outcomes. However, a current challenge is personalizing aging trajectories to promote healthy aging, given the diversity of genotypes and lived experience. We suggest that incorporating heterogeneity-including intrinsic (e.g., genetic and structural) and extrinsic (e.g., environmental and exposome) factors and their interdependence of hallmarks-may move the dial. This editorial perspective will focus on one hallmark, namely mitochondrial dysfunction, to exemplify how consideration of heterogeneity and interdependence or crosstalk may reveal new perspectives and opportunities for personalizing aging research. To this end, we highlight heterogeneity within mitochondria as a model.
衰老的特征一直对指导衰老生物学研究具有重要影响，最近人们越来越认识到这些特征与与年龄相关的健康结果相互依存。然而，鉴于基因型和生活经历的多样性，目前的挑战是使衰老轨迹个性化，以促进健康衰老。我们认为，考虑到异质性，包括内在（例如遗传和结构）和外在（例如环境和外显子组）因素及其特征的相互依存关系，可能会改变这一现状。本社论观点将集中讨论一个特征，即线粒体功能障碍，以此为例说明考虑异质性和相互依存关系或串扰如何为个性化衰老研究提供新的视角和机会。为此，我们强调线粒体内部的异质性作为一个模型。
