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与针对鼠源、大鼠源和人源白细胞介素-2受体的单克隆抗体发生反应的细胞的免疫组织化学定位。

Immunohistochemical localization of cells reacting with monoclonal antibodies directed against the interleukin-2 receptor of murine, rat and human origin.

作者信息

Takacs L, Osawa H, Törö I, Diamantstein T

出版信息

Clin Exp Immunol. 1985 Jan;59(1):37-44.

PMID:3918819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577179/
Abstract

Recently, species specific monoclonal antibodies, directed against the interleukin-2 (IL-2) receptor of murine, rat and human origin, have been produced. In this study we demonstrate with immunohistological methods that cells reacting with these antibodies are present in normal primary and secondary lymphatic organs. The cells are exclusively localized in T cell-dependent areas, and their number increased as a result of immunization.

摘要

最近，已经制备出了针对鼠源、大鼠源和人源白细胞介素-2（IL-2）受体的物种特异性单克隆抗体。在本研究中，我们用免疫组织学方法证明，与这些抗体发生反应的细胞存在于正常的初级和次级淋巴器官中。这些细胞仅定位于T细胞依赖区，并且其数量因免疫而增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa9/1577179/5349c1cad0dd/clinexpimmunol00136-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa9/1577179/9c3fed273f03/clinexpimmunol00136-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa9/1577179/eeb2f6a2692b/clinexpimmunol00136-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa9/1577179/5349c1cad0dd/clinexpimmunol00136-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa9/1577179/9c3fed273f03/clinexpimmunol00136-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa9/1577179/eeb2f6a2692b/clinexpimmunol00136-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa9/1577179/5349c1cad0dd/clinexpimmunol00136-0051-a.jpg

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本文引用的文献

1
Mitogenic effects of partially purified interleukin 2 on thymocyte subpopulations and spleen t cells of the mouse.部分纯化的白细胞介素2对小鼠胸腺细胞亚群和脾T细胞的促有丝分裂作用。
Eur J Immunol. 1980 Sep;10(9):702-7. doi: 10.1002/eji.1830100909.
2
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.一种似乎能识别人类T细胞生长因子受体的单克隆抗体；该受体的部分特性
Nature. 1982 Nov 18;300(5889):267-9. doi: 10.1038/300267a0.
3
Transient expression of interleukin 2 receptors. Consequences for T cell growth.
猕猴灵长类动物的淋巴组织免疫组化
Clin Exp Immunol. 1988 Dec;74(3):435-42.
4
Systemic mononuclear-cell vasculitis in MRL/Mp-lpr/lpr mice. A histologic and immunocytochemical analysis.MRL/Mp-lpr/lpr小鼠的系统性单核细胞性血管炎。组织学和免疫细胞化学分析。
Am J Pathol. 1987 May;127(2):229-42.
5
Expression of Tac antigen in B cell lymphomas.Tac抗原在B细胞淋巴瘤中的表达。
Clin Exp Immunol. 1986 Aug;65(2):354-62.
白细胞介素2受体的瞬时表达。对T细胞生长的影响。
J Exp Med. 1983 Dec 1;158(6):1895-911. doi: 10.1084/jem.158.6.1895.
4
A rat monoclonal antibody that binds specifically to mouse T lymphoblasts and inhibits IL 2 receptor functions: a putative anti-IL 2 receptor antibody.一种能特异性结合小鼠T淋巴母细胞并抑制白细胞介素2受体功能的大鼠单克隆抗体：一种假定的抗白细胞介素2受体抗体。
J Immunol. 1984 May;132(5):2445-50.
5
The characteristics of a monoclonal antibody that binds specifically to rat T lymphoblasts and inhibits IL 2 receptor functions.一种特异性结合大鼠T淋巴母细胞并抑制白细胞介素2受体功能的单克隆抗体的特性。
J Immunol. 1983 Jan;130(1):51-5.