Sheehan E A, Beck F, Clarke C A, Stanisstreet M
Experientia. 1985 Feb 15;41(2):273-5. doi: 10.1007/BF02002633.
In order to investigate further the relationship between maternal diabetes and fetal malformation, rat embryos were grown in vitro in the presence of beta-hydroxybutyrate, one of the ketone bodies produced by diabetics. At 10 mM, beta-hydroxybutyrate produced minor abnormalities and at 20 mM it produced major abnormalities in rat embryos.
为了进一步研究母体糖尿病与胎儿畸形之间的关系，在糖尿病患者产生的酮体之一β-羟基丁酸存在的情况下，将大鼠胚胎进行体外培养。在10毫摩尔浓度时，β-羟基丁酸使大鼠胚胎产生轻微异常，而在20毫摩尔浓度时，则产生严重异常。
