意大利北部蜱传脑炎血清阳性率：一项针对随机选择人群的横断面研究。

Tick-borne encephalitis seroprevalence in northern Italy: a cross-sectional study on a randomly selected population.

作者信息

Castagna Antonella, Schiavon Stefania, Mengozzi Giulio, Baldovin Tatjana, Nozza Silvia, Canetti Diana, Cocchio Silvia, Montuori Eva Agostina, Iantomasi Raffaella, Baldo Vincenzo

机构信息

Clinic of Infectious Diseases, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy.

Ospedale Cà Foncello di Treviso ULSS2 Marca Trevigiana, UOC Microbiologia, Treviso, Italy.

出版信息

IJID Reg. 2024 Jul 14;12:100404. doi: 10.1016/j.ijregi.2024.100404. eCollection 2024 Sep.

DOI:10.1016/j.ijregi.2024.100404

PMID:39188886

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11347062/

Abstract

OBJECTIVES

is under-recognized in Europe. This study aimed to determine the seroprevalence and spatial distribution of tick-borne encephalitis (TBE) virus (TBEV) in areas close to endemic regions in Northern Italy.

METHODS

A multicenter study was conducted on a random sample of the general population afferent to hospitals in Veneto, Lombardy, and Piedmont with a pre-determined sample size of 1500 participants. The presence of TBEV-neutralizing antibodies was determined for sera positive to the TBE-specific immunoglobulin G test in a centralized laboratory.

RESULTS

Out of 1537 samples analyzed (790 from Lombardy, 394 from Veneto, 353 from Piedmont), 39 (2.5%) were immunoglobulin G TBEV-positive. The frequency of positive cases was similar amid the regions (24-3.0% Lombardy, 10-2.5% Veneto, and 5-1.4% Piedmont; = 0.27). The seropositivity rates were 3.6% in subjects aged over 50 years, 2.0% in those aged 30-50 years, and 1.5% in subjects aged under 30 years ( = 0.10). Two of them (one from Veneto and one from Lombardy) were confirmed by TBEV neutralization test (prevalence 130 per 100,000). One lived close to an endemic area (Treviso); the other spent time in an endemic region (Friuli) and did not remember experiencing tick bites.

CONCLUSIONS

The results from this study highlight the need for raising awareness among the population and health care workers to limit the risk of TBE infection.

摘要

目的

在欧洲，蜱传脑炎（TBE）未得到充分认识。本研究旨在确定意大利北部流行地区附近蜱传脑炎病毒（TBEV）的血清阳性率及空间分布。

方法

对威尼托、伦巴第和皮埃蒙特地区医院的普通人群随机样本进行多中心研究，预定样本量为1500名参与者。在一个集中实验室中，对TBE特异性免疫球蛋白G检测呈阳性的血清进行TBEV中和抗体检测。

结果

在分析的1537份样本中（790份来自伦巴第，394份来自威尼托，353份来自皮埃蒙特），39份（2.5%）免疫球蛋白G TBEV呈阳性。各地区阳性病例频率相似（伦巴第为24 - 3.0%，威尼托为10 - 2.5%，皮埃蒙特为5 - 1.4%；P = 0.27）。50岁以上人群血清阳性率为3.6%，30 - 50岁人群为2.0%，30岁以下人群为1.5%（P = 0.10）。其中2例（1例来自威尼托，1例来自伦巴第）经TBEV中和试验确诊（每10万人中患病率为130）。1例居住在流行区附近（特雷维索）；另1例在流行地区（弗留利）停留过，不记得曾被蜱叮咬。