Eckstein Sandra
Abteilung für Palliative Care, Universitätsspital Basel,
Ther Umsch. 2024 Aug;81(4):145-150. doi: 10.23785/TU.2024.04.008.
Dyspnea is a common and distressing symptom in patients with advanced malignant and non-malignant diseases. It is a subjective experience that can only be described by the patients themselves and can be associated with a massive reduction in quality of life, including social isolation and wish to hasten death. Often there is an affective component such as anxiety or panic. Objective parameters do not necessarily correlate with the subjective experience. Health professionals often underestimate and inadequately treat the burden of dyspnea. The introduction of the concept of chronic breathlessness syndrome or acute-on-chronic-breathlessness aims to illustrate the nature of the condition and facilitate the identification and access to appropriate treatment. The management of dyspnea is complex, and for effective treatment, a combination of general, non-pharmacological, and pharmacological measures is usually advisable. Opioids should be offered to patients with incurable cancer and refractory dyspnea for symptom relief. They can be supplemented with benzodiazepines in cases of concomitant anxiety. The administration of oxygen is only indicated in cases of hypoxemia. Key measures include education, self-management skills acquisition and advance care planning for emergency situations.
呼吸困难是晚期恶性和非恶性疾病患者常见且令人痛苦的症状。它是一种主观体验,只能由患者自己描述,并且可能与生活质量大幅下降相关,包括社交孤立和希望加速死亡。通常存在焦虑或恐慌等情感成分。客观参数不一定与主观体验相关。卫生专业人员常常低估并未能充分治疗呼吸困难的负担。引入慢性呼吸急促综合征或急性加重慢性呼吸急促的概念旨在阐明该病症的本质,并促进对适当治疗方法的识别和获取。呼吸困难的管理很复杂,为了进行有效治疗,通常建议综合采用一般措施、非药物措施和药物措施。对于患有无法治愈的癌症且呼吸困难难治的患者,应使用阿片类药物缓解症状。如果伴有焦虑,可辅以苯二氮䓬类药物。仅在低氧血症的情况下才给予氧气。关键措施包括教育、获取自我管理技能以及针对紧急情况的预先护理计划。