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Isolation and characterization of bulgecins, new bacterial metabolites with bulge-inducing activity.

作者信息

Shinagawa S, Maki M, Kintaka K, Imada A, Asai M

出版信息

J Antibiot (Tokyo). 1985 Jan;38(1):17-23. doi: 10.7164/antibiotics.38.17.

DOI:10.7164/antibiotics.38.17
PMID:3918981
Abstract

Bulgecins A, B and C, new bacterial metabolites which induce the formation of bulges by cooperation with beta-lactam antibiotics, were isolated from the culture broth of Pseudomonas mesoacidophila. The three components, separated by column chromatography on QAE-Sephadex A-25, are water-soluble acidic compounds containing a sulfate group in the molecule. Acid hydrolysis showed that D-glucosamine and a new proline derivative are common constituents of the three components. In addition, taurine and beta-alanine are constituents of bulgecins A and B, respectively.

摘要

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