Department of Mother and Child, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, Iasi, Romania.
Clinical Hospital of Obstetrics and Gynecology Cuza Voda, Iasi, Romania.
Reproduction. 2024 Oct 7;168(5). doi: 10.1530/REP-24-0137. Print 2024 Nov 1.
Alpha-ketoglutarate is a common metabolite in the tricarboxylic acid cycle and is central in modulating the reproductive potential in animal models. The present scoping review systematically covers the spectrum of a wide range of evidence from different viewpoints, focusing on the underlying processes and mechanisms of the developmental framework, aiming to fill the gaps within the existing literature.
Alpha-ketoglutarate is an important intermediate molecule in the tricarboxylic acid cycle with a prominent role in distinct biological processes such as cellular energy metabolism, epigenetic regulation, and signaling pathways. We conducted a registered scoping review (OSF: osf.io/b8nyt) to explore the impact of exogenous supplementation on reproductive capabilities. Our strategy included evaluating the main research literature from different databases like PubMed-MEDLINE, Web of ScienceTM, Scopus, and Excerpta Medica dataBASE using a specific systematic layout to encompass all investigations based on experimental models and critically compare the results. Twenty-one studies were included in the main body of this manuscript, which revealed that exogenous supplementation induced dose- and sex-dependent modifications. This metabolite modulates the expression of pluripotency genes, thus controlling stem cells' self-renewal, differentiation, and reprogramming dynamics, while also alleviating structural transformations induced by exposure to heavy metals and other inhibitors. This significantly demonstrated a direct influence of alpha-ketoglutarate in mitigating oxidative stress and prolonging the lifespan, consequently supporting metabolic and endocrine adjustments. It influences oocyte quality and quantity, delays reproductive aging, and establishes an optimal competence framework for development with minimal risk of failure. Therefore, alpha-ketoglutarate is linked to improving reproductive performance, but further studies are needed due to a lack of studies on humans.
α-酮戊二酸是三羧酸循环中的一种常见代谢物，在调节动物模型的生殖潜能方面起着核心作用。本范围界定综述系统地涵盖了来自不同观点的广泛证据，重点关注发育框架的潜在过程和机制，旨在填补现有文献中的空白。
α-酮戊二酸是三羧酸循环中的一种重要中间分子，在细胞能量代谢、表观遗传调控和信号通路等不同生物学过程中发挥着重要作用。我们进行了一项已注册的范围界定综述（OSF：osf.io/b8nyt），以探讨外源性补充对生殖能力的影响。我们的策略包括使用特定的系统布局评估来自 PubMed-MEDLINE、Web of ScienceTM、Scopus 和 Excerpta Medica dataBASE 等不同数据库的主要研究文献，以涵盖所有基于实验模型的研究，并批判性地比较结果。本文主要部分纳入了 21 项研究，这些研究表明外源性补充会引起剂量和性别依赖性的改变。这种代谢物调节多能性基因的表达，从而控制干细胞的自我更新、分化和重编程动态，同时减轻暴露于重金属和其他抑制剂引起的结构转化。这显著证明了α-酮戊二酸在减轻氧化应激和延长寿命方面的直接影响，从而支持代谢和内分泌的调整。它影响卵母细胞的质量和数量，延缓生殖衰老，并建立一个最佳的发展能力框架，风险最小化。因此，α-酮戊二酸与提高生殖性能有关，但由于缺乏对人类的研究，还需要进一步研究。
