Gahl W A, Bercu B B
J Clin Endocrinol Metab. 1985 Apr;60(4):793-6. doi: 10.1210/jcem-60-4-793.
We investigated whether long term cysteamine therapy in cystinotic children altered their basal and stimulated serum PRL levels. Five subjects who had normal plasma PRL responses to TRH stimulation before cysteamine treatment each had a lower basal PRL level and a blunted PRL response during long term (19-59 months) cysteamine therapy. A blunted PRL response was not found in 12 cystinotic subjects of the same age and stage of disease who had not received cysteamine. The effect on PRL release was not found in 2 subjects who received short term (1-2 weeks) treatment with full-dose cysteamine (50 mg/kg . day). The TSH response to TRH stimulation was not blunted during long term cysteamine therapy. These findings suggest that cysteamine alters PRL secretion in humans.
我们研究了胱氨酸病患儿长期使用半胱胺治疗是否会改变其基础血清催乳素（PRL）水平及刺激后的血清PRL水平。5名在半胱胺治疗前对促甲状腺激素释放激素（TRH）刺激有正常血浆PRL反应的受试者，在长期（19 - 59个月）半胱胺治疗期间，各自的基础PRL水平较低，且PRL反应减弱。在12名未接受半胱胺治疗、年龄和疾病阶段相同的胱氨酸病受试者中未发现PRL反应减弱。2名接受全剂量半胱胺（50 mg/kg·天）短期（1 - 2周）治疗的受试者未出现对PRL释放的影响。长期半胱胺治疗期间，TSH对TRH刺激的反应未减弱。这些发现表明半胱胺会改变人体PRL的分泌。
