人血浆中脂质过氧化氢的存在。
Presence of lipid hydroperoxide in human plasma.
作者信息
Warso M A, Lands W E
出版信息
J Clin Invest. 1985 Feb;75(2):667-71. doi: 10.1172/JCI111745.
Abstract
Using purified prostaglandin (PG) H synthase, which synthesizes PGG2 and PGH2 from arachidonic acid, we were able to assay for the presence of peroxide activators in biological tissues. This assay system, capable of detecting both hydrogen peroxide (H2O2) and lipid hydroperoxides, detected a significant amount of synthase activator in plasma. Treatment of the active preparations with catalase and glutathione peroxidase showed that the principal activator in normal human plasma was a lipid hydroperoxide rather than H2O2.
摘要
利用从花生四烯酸合成前列腺素（PG）G2和PGH2的纯化前列腺素（PG）H合酶，我们能够检测生物组织中过氧化物激活剂的存在。该检测系统能够检测过氧化氢（H2O2）和脂质氢过氧化物，在血浆中检测到大量的合酶激活剂。用过氧化氢酶和谷胱甘肽过氧化物酶处理活性制剂表明，正常人血浆中的主要激活剂是脂质氢过氧化物而非H2O2。
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