No information is available on the clinical use of sebelipase alfa during breastfeeding. Because it is a large protein molecule with a molecular weight of about 55,000 Da, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. If sebelipase alfa is required by the mother, it is not a reason to discontinue breastfeeding. Until more data are available, sebelipase alfa should be used with infant careful monitoring during breastfeeding.
关于司美格鲁肽在母乳喂养期间的临床应用尚无可用信息。由于它是一种分子量约为55,000道尔顿的大蛋白质分子，乳汁中的含量可能非常低，而且由于它可能会在婴儿胃肠道中被破坏，所以不太可能被吸收。如果母亲需要使用司美格鲁肽，这并不是停止母乳喂养的理由。在获得更多数据之前，母乳喂养期间使用司美格鲁肽时应密切监测婴儿情况。
