Venter Carina, Pickett-Nairne Kaci, Leung Donald, Fleischer David, O'Mahony Liam, Glueck Deborah H, Dabelea Dana
Section of Allergy and Immunology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
Children's Hospital Colorado, Aurora, Colorado, USA.
Allergy. 2024 Dec;79(12):3475-3488. doi: 10.1111/all.16292. Epub 2024 Aug 28.
Studies of childhood diet diversity and allergic disease have not examined additional associations with an offspring allergy-linked maternal diet index during pregnancy. We studied both associations in a pre-birth cohort.
Offspring allergic disease diagnoses were obtained from electronic medical records. Maternal and infant diet were self-reported. Adjusted parametric Weibull time-to-event models assessed associations between maternal diet index, infant diet diversity and time to development of allergic rhinitis, atopic dermatitis, asthma, wheeze, IgE-mediated food allergy, and a combined outcome of any allergic disease except for wheeze.
Infant diet diversity at 1 year was associated with the risk of the combined outcome between 1 and 4 years of age (p = .002). While both maternal diet index and infant diet diversity at 1 year were associated with the risk of the combined outcome between 1 and 4 years of age (both p < .05), infant diet diversity at 1 year did not modify the association between maternal diet index and the risk of the combined outcome between 1 and 4 years of age (p = .5). The group with the lowest risk of the combined allergy outcome had higher maternal diet index and higher infant diet diversity.
The novel finding that both maternal diet index during pregnancy and infant diet diversity at 12 months are associated with the risk of a combined allergic disease outcome points to two targets for preventive interventions: maternal diet index scores during pregnancy and offspring diet diversity during infancy.
关于儿童饮食多样性与过敏性疾病的研究尚未探讨孕期与后代过敏相关的母亲饮食指数之间的其他关联。我们在一个出生前队列中研究了这两种关联。
从电子病历中获取后代过敏性疾病的诊断信息。母亲和婴儿的饮食情况通过自我报告获得。调整后的参数韦布尔生存时间模型评估了母亲饮食指数、婴儿饮食多样性与过敏性鼻炎、特应性皮炎、哮喘、喘息、IgE介导的食物过敏以及除喘息外的任何过敏性疾病综合结果的发病时间之间的关联。
1岁时婴儿的饮食多样性与1至4岁时综合结果的风险相关（p = 0.002）。虽然母亲饮食指数和1岁时婴儿饮食多样性均与1至4岁时综合结果的风险相关（p均<0.05），但1岁时婴儿饮食多样性并未改变母亲饮食指数与1至4岁时综合结果风险之间的关联（p = 0.5）。综合过敏结果风险最低的组母亲饮食指数较高且婴儿饮食多样性较高。
孕期母亲饮食指数和12个月时婴儿饮食多样性均与综合过敏性疾病结果的风险相关这一新颖发现指出了预防干预的两个目标：孕期母亲饮食指数得分和婴儿期后代饮食多样性。
