Section of Allergy & Immunology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
Children's Hospital Colorado, Aurora, CO, USA.
Allergy. 2022 Jan;77(1):162-172. doi: 10.1111/all.14949. Epub 2021 Jun 9.
A systematic review showed limited associations between pregnancy diet and offspring allergy. We developed a maternal diet index during pregnancy that was associated with offspring allergy outcomes.
Data came from Healthy Start, a Colorado pre-birth cohort of mother/offspring dyads. Food propensity questionnaires were completed during pregnancy. Offspring allergic rhinitis, atopic dermatitis, asthma, wheeze, and food allergy diagnosis up to age four were verified from electronic medical records. Data were randomized into test and replication sets. The index included the weighted combination of variables that best predicted a combined outcome of any allergy in the test set. Index utility was verified in the replication set. Separate adjusted and unadjusted logistic models estimated associations between the index and each offspring allergy diagnosis in the full sample.
The index included weighted measures of intake of vegetables, yogurt, fried potatoes, rice/grains, red meats, pure fruit juice, and cold cereals. Vegetables and yogurt were associated with the prevention of any allergy, while other components were associated with increased disease. In adjusted models, a one-unit increase in the index was significantly associated with reduced odds of offspring allergic rhinitis (odds ratio (CI) 0.82 [0.72-0.94]), atopic dermatitis (0.77 [0.69-0.86]), asthma (0.84 [0.74-0.96]), and wheeze (0.80 [0.71-0.90]), but not food allergy (0.84 [0.66-1.08]).
This is the first study that has shown associations between an index of maternal dietary intake during pregnancy and multiple offspring allergic diseases. The results give hope for prevention of allergic diseases in utero.
系统评价显示，孕期饮食与后代过敏之间的关联有限。我们开发了一种孕期母体饮食指数，该指数与后代过敏结局相关。
数据来自科罗拉多州产前母婴对子的健康开端研究。孕期完成食物倾向问卷。从电子病历中验证了 4 岁以下儿童的过敏性鼻炎、特应性皮炎、哮喘、喘息和食物过敏诊断。数据随机分为测试和复制集。该指数包括在测试集中最佳预测任何过敏综合结局的变量的加权组合。在复制集中验证了指数的有效性。在全样本中，分别使用调整和未调整的逻辑模型估计了指数与每种后代过敏诊断之间的关联。
该指数包括蔬菜、酸奶、炸薯条、大米/谷物、红色肉类、纯果汁和冷麦片摄入量的加权指标。蔬菜和酸奶与预防任何过敏有关，而其他成分与疾病增加有关。在调整模型中，指数每增加一个单位，与后代患过敏性鼻炎（比值比（CI）0.82[0.72-0.94]）、特应性皮炎（0.77[0.69-0.86]）、哮喘（0.84[0.74-0.96]）和喘息（0.80[0.71-0.90]）的几率降低显著相关，但与食物过敏（0.84[0.66-1.08]）无关。
这是第一项表明孕期母体饮食摄入指数与多种后代过敏疾病之间存在关联的研究。这些结果为宫内预防过敏疾病带来了希望。
