血清和滑液对干扰素的灭活作用。
Inactivation of interferon by serum and synovial fluids.
作者信息
O'Kelly P, Thomsen L, Tilles J G, Cesario T
出版信息
Proc Soc Exp Biol Med. 1985 Mar;178(3):407-11. doi: 10.3181/00379727-178-42024.
PMID:3919398
Abstract
The stability of interferons-alpha, -beta, and -gamma (IFN) in serum and synovial fluids were compared. Interferon-beta was the least stable interferon species, losing at least 75% of its activity during incubation in samples of both serum and synovial fluid. Interferon-alpha was the most stable IFN, but interferon-gamma under these conditions approached the stability of the alpha species. The inactivation of IFN-beta was found due to dialyzable factors and hence not classical antibodies.
摘要
比较了α、β和γ干扰素（IFN）在血清和滑液中的稳定性。β干扰素是最不稳定的干扰素种类，在血清和滑液样本孵育期间至少丧失其75%的活性。α干扰素是最稳定的IFN，但在这些条件下γ干扰素的稳定性接近α干扰素。发现β干扰素的失活是由于可透析因子，因此不是经典抗体所致。
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