DeGré M, Mellbye O J, Clarke-Jenssen O
Ann Rheum Dis. 1983 Dec;42(6):672-6. doi: 10.1136/ard.42.6.672.
Moderate titres of antiviral activity were demonstrated in 48-58% of sera obtained from patients suffering from seropositive and seronegative rheumatoid arthritis (RA), psoriatic arthritis, Reiter's syndrome, ankylosing spondylitis, and juvenile rheumatoid arthritis. Sera from blood donors and from patients with various noninflammatory diseases were positive in 16% of cases. The activity was species-specific, mediated by the homologous cells, and destroyed by treatment with trypsin and exposure to pH 2. Antibodies against human IFN-alpha did not neutralise the activity. These characteristics are compatible with those of IFN-gamma or immune interferon. Neither the presence nor the titre of IFN was correlated with disease activity defined by concentration of C-reactive protein, C3 concentration, and erythrocyte sedimentation rate. IFN-gamma was present in 4 of 10 synovial fluids from patients with RA. The titre in one of these was higher than in the corresponding serum, indicating local production in the rheumatoid joint.
在患有血清阳性和血清阴性类风湿性关节炎(RA)、银屑病关节炎、赖特综合征、强直性脊柱炎和青少年类风湿性关节炎的患者所提供的血清中,48% - 58%显示出中等滴度的抗病毒活性。来自献血者和患有各种非炎性疾病患者的血清在16%的病例中呈阳性。该活性具有种属特异性,由同源细胞介导,并通过胰蛋白酶处理和暴露于pH 2而被破坏。抗人IFN-α抗体不能中和该活性。这些特征与IFN-γ或免疫干扰素的特征相符。IFN的存在与否及滴度均与由C反应蛋白浓度、C3浓度和红细胞沉降率所定义的疾病活动度无关。在10例RA患者的滑膜液中,有4例存在IFN-γ。其中1例的滴度高于相应血清中的滴度,表明在类风湿关节中存在局部产生。