类风湿关节炎及相关病症患者血清和滑液中的免疫干扰素
Immune interferon in serum and synovial fluid in rheumatoid arthritis and related disorders.
作者信息
DeGré M, Mellbye O J, Clarke-Jenssen O
出版信息
Ann Rheum Dis. 1983 Dec;42(6):672-6. doi: 10.1136/ard.42.6.672.
Abstract
Moderate titres of antiviral activity were demonstrated in 48-58% of sera obtained from patients suffering from seropositive and seronegative rheumatoid arthritis (RA), psoriatic arthritis, Reiter's syndrome, ankylosing spondylitis, and juvenile rheumatoid arthritis. Sera from blood donors and from patients with various noninflammatory diseases were positive in 16% of cases. The activity was species-specific, mediated by the homologous cells, and destroyed by treatment with trypsin and exposure to pH 2. Antibodies against human IFN-alpha did not neutralise the activity. These characteristics are compatible with those of IFN-gamma or immune interferon. Neither the presence nor the titre of IFN was correlated with disease activity defined by concentration of C-reactive protein, C3 concentration, and erythrocyte sedimentation rate. IFN-gamma was present in 4 of 10 synovial fluids from patients with RA. The titre in one of these was higher than in the corresponding serum, indicating local production in the rheumatoid joint.
摘要
在患有血清阳性和血清阴性类风湿性关节炎（RA）、银屑病关节炎、赖特综合征、强直性脊柱炎和青少年类风湿性关节炎的患者所提供的血清中，48% - 58%显示出中等滴度的抗病毒活性。来自献血者和患有各种非炎性疾病患者的血清在16%的病例中呈阳性。该活性具有种属特异性，由同源细胞介导，并通过胰蛋白酶处理和暴露于pH 2而被破坏。抗人IFN-α抗体不能中和该活性。这些特征与IFN-γ或免疫干扰素的特征相符。IFN的存在与否及滴度均与由C反应蛋白浓度、C3浓度和红细胞沉降率所定义的疾病活动度无关。在10例RA患者的滑膜液中，有4例存在IFN-γ。其中1例的滴度高于相应血清中的滴度，表明在类风湿关节中存在局部产生。
相似文献
1
Immune interferon in serum and synovial fluid in rheumatoid arthritis and related disorders.类风湿关节炎及相关病症患者血清和滑液中的免疫干扰素
Ann Rheum Dis. 1983 Dec;42(6):672-6. doi: 10.1136/ard.42.6.672.
2
Immunoelectrophoretic assay for synovial fluid C3 with correction for synovial fluid globulin.用于检测滑液C3并校正滑液球蛋白的免疫电泳分析。
Arthritis Rheum. 1979 Mar;22(3):243-50. doi: 10.1002/art.1780220306.
3
Effect of Sanhuangyilong decoction plus methotrexate on tumor necrosis factor alpha and interferon gamma in serum and synovial fluid in rheumatoid arthritis patients with symptom pattern of damp heat obstruction.三黄一龙汤加甲氨蝶呤对湿热痹阻型类风湿关节炎患者血清及关节液中肿瘤坏死因子α和干扰素γ的影响
J Tradit Chin Med. 2016 Oct;36(5):625-33. doi: 10.1016/s0254-6272(16)30082-6.
4
Synovial fluid levels of anti-cyclic citrullinated peptide antibodies and IgA rheumatoid factor in rheumatoid arthritis, psoriatic arthritis, and osteoarthritis.类风湿关节炎、银屑病关节炎和骨关节炎中抗环瓜氨酸肽抗体和 IgA 类风湿因子的滑液水平。
Arthritis Rheum. 2006 Feb 15;55(1):53-6. doi: 10.1002/art.21691.
5
Activation of complement components C3 and factor B in synovial fluids.滑液中补体成分C3和B因子的激活。
J Lab Clin Med. 1977 Jan;89(1):160-71.
6
Virus antibodies in serum and synovial fluid of patients with rheumatoid arthritis and other connective tissue diseases.类风湿性关节炎及其他结缔组织疾病患者血清和滑液中的病毒抗体。
Ann Rheum Dis. 1975 Feb;34(1):43-8. doi: 10.1136/ard.34.1.43.
7
Serum and synovial fluid Ig, C3 and CRP levels in rheumatoid arthritis.类风湿关节炎患者血清及滑液中的免疫球蛋白、C3和C反应蛋白水平
Arch Roum Pathol Exp Microbiol. 1981 Oct-Dec;40(4):305-11.
8
[Study of C3 and C4 complement components of synovial fluids in connective tissue diseases (author's transl)].结缔组织疾病中滑液C3和C4补体成分的研究（作者译）
Allerg Immunol (Leipz). 1978;24(3):167-74.
9
Survey of synovial fluid cryoprecipitates.滑膜液冷沉淀物调查。
Ann Rheum Dis. 1980 Jun;39(3):253-9. doi: 10.1136/ard.39.3.253.
10
Cytokines in synovial fluid: II. The presence of tumour necrosis factor and interferon.滑液中的细胞因子：II. 肿瘤坏死因子和干扰素的存在
Clin Exp Immunol. 1988 Jul;73(1):88-92.
引用本文的文献
1
Ameliorative Effects of a Polyphenolic Fraction of Cinnamomum zeylanicum L. Bark in Animal Models of Inflammation and Arthritis.锡兰肉桂树皮多酚组分对炎症和关节炎动物模型的改善作用
Sci Pharm. 2013 Apr-Jun;81(2):567-89. doi: 10.3797/scipharm.1301-16. Epub 2013 Feb 25.
2
Transcriptional modulation of cartilage-specific collagen gene expression by interferon gamma and tumour necrosis factor alpha in cultured human chondrocytes.干扰素γ和肿瘤坏死因子α对培养的人软骨细胞中软骨特异性胶原基因表达的转录调控
Biochem J. 1993 Sep 15;294 ( Pt 3)(Pt 3):761-9. doi: 10.1042/bj2940761.
3
Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon gamma.炎性滑液对单核细胞效应基因和STAT家族转录因子的激活不依赖于γ干扰素。
J Exp Med. 1995 Mar 1;181(3):1015-25. doi: 10.1084/jem.181.3.1015.
4
Synthesis of antibodies, including antiviral antibodies, in the knee joints of patients with arthritis.关节炎患者膝关节中抗体的合成，包括抗病毒抗体的合成。
Ann Rheum Dis. 1985 Nov;44(11):734-7. doi: 10.1136/ard.44.11.734.
5
6
Natural killer (NK) cells at inflammatory sites of patients with rheumatoid arthritis and IgM rheumatoid factor positive polyarticular juvenile rheumatoid arthritis.类风湿关节炎患者及IgM类风湿因子阳性多关节型幼年特发性关节炎患者炎症部位的自然杀伤（NK）细胞
Clin Rheumatol. 1987 Jun;6(2):215-25. doi: 10.1007/BF02201027.
7
Conditioned medium from stimulated mononuclear leucocytes potentiates the ability of human neutrophils to damage human articular cartilage.来自受刺激单核白细胞的条件培养基增强了人类中性粒细胞损伤人类关节软骨的能力。
Ann Rheum Dis. 1988 Jan;47(1):1-9. doi: 10.1136/ard.47.1.1.
8
Results of a multicenter placebo-controlled double-blind randomized phase III clinical study of treatment of rheumatoid arthritis with recombinant interferon-gamma.重组干扰素-γ治疗类风湿关节炎的多中心安慰剂对照双盲随机III期临床研究结果
Rheumatol Int. 1988;8(2):87-93. doi: 10.1007/BF00271840.
9
Effect of recombinant cytokines on glycolysis and fructose 2,6-bisphosphate in rheumatoid synovial cells in vitro.重组细胞因子对类风湿性滑膜细胞体外糖酵解及果糖-2,6-二磷酸的影响
Biochem J. 1988 Feb 15;250(1):111-5. doi: 10.1042/bj2500111.
10
Immunoreactive IFN-gamma in CSF in neurological disorders.神经系统疾病患者脑脊液中免疫反应性γ-干扰素
J Neurol Neurosurg Psychiatry. 1987 Jul;50(7):882-5. doi: 10.1136/jnnp.50.7.882.
本文引用的文献
1
Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin.植物血凝素在人白细胞中诱导产生的类干扰素病毒抑制剂。
Science. 1965 Jul 16;149(3681):310-1.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
1958 Revision of diagnostic criteria for rheumatoid arthritis.1958年类风湿关节炎诊断标准修订版。
Bull Rheum Dis. 1958 Dec;9(4):175-6.
4
Natural killer (NK) cell activity of peripheral blood, synovial fluid, and synovial tissue lymphocytes from patients with rheumatoid arthritis and juvenile rheumatoid arthritis.类风湿关节炎和青少年类风湿关节炎患者外周血、滑液及滑膜组织淋巴细胞的自然杀伤（NK）细胞活性。
Ann Rheum Dis. 1982 Oct;41(5):490-4. doi: 10.1136/ard.41.5.490.
5
Multiple interferons in the circulation of patients with systemic lupus erythematosus and vasculitis.系统性红斑狼疮和血管炎患者循环中的多种干扰素。
Arthritis Rheum. 1982 Apr;25(4):396-400. doi: 10.1002/art.1780250406.
6
Immune interferon release when a cloned cytotoxic T-cell line meets its correct influenza-infected target cell.当一个克隆的细胞毒性T细胞系与正确的流感感染靶细胞相遇时，免疫干扰素会释放。
Nature. 1982 Jan 14;295(5845):150-2. doi: 10.1038/295150a0.
7
Treatment of NZB/NZW F1 hybrid mice with Mycobacterium bovis strain BCG or type II interferon preparations accelerates autoimmune disease.
Arthritis Rheum. 1981 Nov;24(11):1396-1402. doi: 10.1002/art.1780241110.
8
Production of immune interferon (type II) in cocultures of mouse peritoneal macrophages and syngeneic tumour cells.小鼠腹腔巨噬细胞与同基因肿瘤细胞共培养体系中免疫干扰素（Ⅱ型）的产生
Scand J Immunol. 1981;13(6):605-8. doi: 10.1111/j.1365-3083.1981.tb00175.x.
9
Immune interferon induction by monoclonal antibody specific for human T cells.
Cell Immunol. 1981 Nov 1;64(2):304-11. doi: 10.1016/0008-8749(81)90482-2.
10
Human gamma interferon production by leukocytes induced with monoclonal antibodies recognizing T cells.用识别T细胞的单克隆抗体诱导白细胞产生人γ干扰素。
J Immunol. 1981 Sep;127(3):1197-200.
Zotero 插件