Jones C, Morse H G, Kao F T, Carbone A, Palmer E
Science. 1985 Apr 5;228(4695):83-5. doi: 10.1126/science.3919444.
The genes encoding the alpha chain of the human T-cell receptor have been mapped to chromosome 14, the chromosome on which the human immunoglobulin heavy chain locus resides. Thus, genes encoding two different classes of antigen receptor are present on the same chromosome. Furthermore, breaks involving chromosome 14 are frequently seen in tumors of T-cell origin. The potential relation of these chromosome abnormalities to alpha-chain genes is discussed.
编码人类T细胞受体α链的基因已被定位到14号染色体，即人类免疫球蛋白重链基因座所在的染色体。因此，编码两类不同抗原受体的基因存在于同一条染色体上。此外，在T细胞起源的肿瘤中经常可以看到涉及14号染色体的断裂。本文讨论了这些染色体异常与α链基因之间的潜在关系。
