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提取物通过激活OR2AT4促进伤口愈合并具有抗炎活性。

Extract Promotes Wound Healing through OR2AT4 Activation and Exhibits Anti-Inflammatory Activity.

作者信息

Choo Jung Ha, Kim Daehyun, Min Kyoungin, Lee So Young, Kang Nae Gyu

机构信息

Science Research Park, LG Household and Healthcare Ltd., Gangseo-gu, Seoul 07795, Republic of Korea.

出版信息

Curr Issues Mol Biol. 2024 Aug 21;46(8):9136-9148. doi: 10.3390/cimb46080540.

DOI:10.3390/cimb46080540
PMID:39194757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11353136/
Abstract

Skin healing occurs through an intricate process called wound healing which comprises four phases: coagulation and hemostasis, inflammation, cellular proliferation, and remodeling. Chronic wounds often arise because of prolonged or excessive inflammation, which hinders the healing process and wound closure. Despite the recognized efficacy of (patchouli) in wound healing, the precise mechanism of action of extract (PCE) on inflammation and wound healing remains poorly understood. In this study, we investigated the effects of PCE on cell proliferation and wound healing, as well as its anti-inflammatory activity, using in vitro experiments. We found that PCE increased cell proliferation and expression of the cell proliferation marker Ki67 and accelerated wound healing in human keratinocytes through the activation of OR2AT4. Furthermore, PCE exhibited anti-inflammatory effects by decreasing the levels of pro-inflammatory cytokines interleukin-6 and -8 in lipopolysaccharide-treated and TNF-α-exposed THP-1 and HaCaT cells, respectively. Overall, these findings suggest that PCE holds therapeutic potential by promoting cell proliferation, facilitating wound healing, and exerting anti-inflammatory effects.

摘要

皮肤愈合是通过一个称为伤口愈合的复杂过程发生的，该过程包括四个阶段：凝血和止血、炎症、细胞增殖和重塑。慢性伤口通常是由于炎症持续时间过长或过度而产生的，这会阻碍愈合过程和伤口闭合。尽管广藿香在伤口愈合方面的功效已得到认可，但广藿香提取物（PCE）对炎症和伤口愈合的确切作用机制仍知之甚少。在本研究中，我们使用体外实验研究了PCE对细胞增殖和伤口愈合的影响及其抗炎活性。我们发现，PCE通过激活OR2AT4增加了细胞增殖和细胞增殖标志物Ki67的表达，并加速了人角质形成细胞的伤口愈合。此外，PCE分别通过降低脂多糖处理的THP-1细胞和TNF-α刺激的HaCaT细胞中促炎细胞因子白细胞介素-6和-8的水平，表现出抗炎作用。总体而言，这些发现表明，PCE通过促进细胞增殖、促进伤口愈合和发挥抗炎作用具有治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab6/11353136/08391b1d3fba/cimb-46-00540-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab6/11353136/de11492e60f0/cimb-46-00540-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab6/11353136/87525450b00c/cimb-46-00540-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab6/11353136/b36aaedc252e/cimb-46-00540-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab6/11353136/ed80d92f2b07/cimb-46-00540-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab6/11353136/08391b1d3fba/cimb-46-00540-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab6/11353136/de11492e60f0/cimb-46-00540-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab6/11353136/87525450b00c/cimb-46-00540-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab6/11353136/b36aaedc252e/cimb-46-00540-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab6/11353136/ed80d92f2b07/cimb-46-00540-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab6/11353136/08391b1d3fba/cimb-46-00540-g005.jpg

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OR2AT4 and OR1A2 counterregulate molecular pathophysiological processes of steroid-resistant inflammatory lung diseases in human alveolar macrophages.OR2AT4 和 OR1A2 可拮抗人肺泡巨噬细胞中类固醇抵抗性炎症性肺疾病的分子病理生理过程。
Mol Med. 2022 Dec 12;28(1):150. doi: 10.1186/s10020-022-00572-8.
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Polysaccharides From (Blanco) Benth.: Characterization and Antioxidant Activities.来自（布兰科）本特的多糖：表征与抗氧化活性。
Front Pharmacol. 2022 Jun 16;13:933669. doi: 10.3389/fphar.2022.933669. eCollection 2022.
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