Departement of Pharmacy, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.
Departement of Chemistry, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.
Molecules. 2023 Feb 21;28(5):2020. doi: 10.3390/molecules28052020.
Research on the manufacture of hydrogel films from polyvinyl alcohol, corn starch, patchouli oil, and silver nanoparticles, (PVA/CS/PO/AgNPs, respectively) was completed. The silver nanoparticles used in this study resulted from green synthesis using local patchouli plants ( Benth). Aqueous patchouli leaf extract (APLE) and methanol patchouli leaf extract (MPLE) are used in the synthesis of phytochemicals (green synthesis), which are then blended in the production of PVA/CS/PO/AgNPs hydrogel films, which are then cross linked with glutaraldehyde. The results demonstrated that the hydrogel film was flexible, easy to fold, and free of holes and air bubbles. The presence of hydrogen bonds between the functional groups of PVA, CS, and PO was revealed using FTIR spectroscopy. SEM analysis revealed that the hydrogel film was slightly agglomerated and did not exhibit cracking or pinholes. The analysis of pH, spreadability, gel fraction, and swelling index showed that the resulting PVA/CS/PO/AgNP hydrogel films met expected standards except for the organoleptic properties of the resulting colors, which tended to be slightly darker in color. The formula with silver nanoparticles synthesized in methanolic of patchouli leaf extract (AgMENPs) had the highest thermal stability compared to hydrogel films with silver nanoparticles synthesized in aqueous of patchouli leaf extract (AgAENPs). The hydrogel films can be safely used up to 200 °C. The antibacterial studies revealed that the films inhibited the growth of both and , as determined by the disc diffusion method, with the best antibacterial activity being against . In conclusion, the hydrogel film F, loaded with silver nanoparticles biosynthesized in aqueous of patchouli leave extract (AgAENPs) and light fraction of patchouli oil (LFoPO) performed the best activity against both and .
完成了由聚乙烯醇、玉米淀粉、广藿香油和银纳米粒子（分别为 PVA/CS/PO/AgNPs）制成的水凝胶薄膜的研究。本研究中使用的银纳米粒子是通过利用当地广藿香植物（Benth）进行绿色合成得到的。水提广藿香叶提取物（APLE）和甲醇提广藿香叶提取物（MPLE）被用于植物化学物质的合成（绿色合成），然后将其混合在 PVA/CS/PO/AgNPs 水凝胶薄膜的生产中，然后用戊二醛交联。结果表明，水凝胶薄膜具有柔韧性、易于折叠、无孔和无气泡。傅里叶变换红外光谱（FTIR）分析表明，PVA、CS 和 PO 的官能团之间存在氢键。SEM 分析表明，水凝胶薄膜略有团聚，没有出现裂纹或针孔。对 pH 值、铺展性、凝胶分数和溶胀指数的分析表明，所得到的 PVA/CS/PO/AgNP 水凝胶薄膜除了颜色的感官特性外，都符合预期的标准，所得到的颜色往往略深。与由水提广藿香叶提取物（AgAENPs）合成的银纳米粒子相比，由甲醇提广藿香叶提取物（AgMENPs）合成的银纳米粒子的水凝胶薄膜具有更高的热稳定性。水凝胶薄膜在 200°C 以下可安全使用。抑菌研究表明，薄膜通过圆盘扩散法抑制了 和 的生长，抑菌活性最好的是 。总之，负载由水提广藿香叶提取物（AgAENPs）和轻馏分广藿香油（LFoPO）合成的银纳米粒子的水凝胶薄膜 F 对 和 都具有最佳的活性。
