Division of Cardiology, Department of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Department of Physical Medicine and Rehabilitation and Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA.
Nat Cardiovasc Res. 2024 Feb;3(2):118-129. doi: 10.1038/s44161-023-00414-8. Epub 2024 Jan 18.
Throughout the COVID-19 pandemic, the new clinical entity of the post-COVID-19 condition, defined as a multisystemic condition of persistent symptoms following resolution of an acute severe acute respiratory syndrome coronavirus 2 infection, has emerged as an important area of clinical focus. While this syndrome spans multiple organ systems, cardiovascular complications are often the most prominent features. These include, but are not limited to, myocardial injury, heart failure, arrhythmias, vascular injury/thrombosis and dysautonomia. As the number of individuals with the post-COVID-19 condition continues to climb and overwhelm medical systems, summarizing existing information and knowledge gaps in the complex cardiovascular effects of the post-COVID-19 condition has become critical for patient care. In this Review, we explore the current state of knowledge of the post-COVID-19 condition and identify areas where additional research is warranted. This will provide a framework for better understanding the cardiovascular manifestations of the post-COVID-19 condition with a focus on pathophysiology, diagnosis and management.
在整个 COVID-19 大流行期间，一种新的临床实体——COVID-19 后状况，被定义为急性严重急性呼吸系统综合症冠状病毒 2 感染消退后持续存在的多系统症状，已成为临床关注的重要领域。虽然这种综合征涉及多个器官系统，但心血管并发症通常是最突出的特征。这些并发症包括但不限于心肌损伤、心力衰竭、心律失常、血管损伤/血栓形成和自主神经功能障碍。随着 COVID-19 后状况患者的数量不断增加并使医疗系统不堪重负，总结 COVID-19 后状况对心血管系统复杂影响方面的现有信息和知识空白对于患者护理变得至关重要。在这篇综述中，我们探讨了 COVID-19 后状况的现有知识状况，并确定了需要进一步研究的领域。这将为更好地理解 COVID-19 后状况的心血管表现提供一个框架，重点关注病理生理学、诊断和管理。
