Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Mol Cell Biochem. 2021 Oct;476(10):3591-3600. doi: 10.1007/s11010-021-04182-6. Epub 2021 May 21.
Bone morphogenetic protein 9 (BMP9) is a recently discovered cytokine mainly secreted by the liver and is a member of the transforming growth factor β (TGF-β) superfamily. In recent years, an increasing number of studies have shown that BMP9 is associated with liver diseases, including nonalcoholic fatty liver disease (NAFLD), liver fibrosis and hepatocellular carcinoma (HCC), and BMP9 signaling may play dual roles in liver diseases. In this review, we mainly summarized and discussed the roles and potential mechanisms of BMP9 signaling in NAFLD, liver fibrosis and HCC. Specifically, this article will provide a better understanding of BMP9 signaling and new clues for the treatment of liver diseases.
骨形态发生蛋白 9（BMP9）是一种最近发现的细胞因子，主要由肝脏分泌，是转化生长因子 β（TGF-β）超家族的成员。近年来，越来越多的研究表明，BMP9 与肝脏疾病有关，包括非酒精性脂肪性肝病（NAFLD）、肝纤维化和肝细胞癌（HCC），BMP9 信号可能在肝脏疾病中发挥双重作用。在这篇综述中，我们主要总结和讨论了 BMP9 信号在 NAFLD、肝纤维化和 HCC 中的作用和潜在机制。具体来说，本文将提供对 BMP9 信号的更好理解，并为肝脏疾病的治疗提供新的线索。
