Wallace Gordon George
Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, Squires Way, North Wollongong, NSW 2500, Australia.
Bioengineering (Basel). 2024 Aug 22;11(8):856. doi: 10.3390/bioengineering11080856.
More than three decades ago, we embarked on a number of bioengineering explorations using the most advanced materials and fabrication methods. In every area we ventured into, it was our intention to ensure fundamental discoveries were deployed into the clinic to benefit patients. When we embarked on this journey, we did so without a road map, not even a compass, and so the path was arduous, sometimes tedious. Now, we can see the doorway to deployment on the near horizon. We now appreciate that overcoming the challenges has made this a rewarding and exciting journey. However, maybe we could have been here a lot sooner, and so maybe the lessons we have learned could benefit others and accelerate progress in clinical translation. Through a number of case studies, including neural regeneration, cartilage regeneration, skin regeneration, the 3D printing of capsules for islet cell transplantation, and the bioengineered cornea, here, we retrace our steps. We will summarise the journey to date, point out the obstacles encountered, and celebrate the translational impact. Then, we will provide a framework for project design with the clinical deployment of bioengineered products as the goal.
三十多年前，我们利用最先进的材料和制造方法开展了一系列生物工程探索。在我们涉足的每一个领域，我们都旨在确保将基础研究成果应用于临床，以造福患者。当我们踏上这段征程时，我们没有路线图，甚至没有指南针，因此道路崎岖，有时还很乏味。现在，我们可以看到临床应用的大门已近在眼前。我们现在认识到，克服这些挑战使这段旅程变得有意义且令人兴奋。然而，也许我们本可以更早到达这里，所以我们学到的经验教训或许能让其他人受益，并加速临床转化的进程。通过一系列案例研究，包括神经再生、软骨再生、皮肤再生、用于胰岛细胞移植的胶囊的3D打印以及生物工程角膜，在此，我们回顾我们的历程。我们将总结迄今为止的旅程，指出遇到的障碍，并赞颂其转化影响。然后，我们将以生物工程产品的临床应用为目标，提供一个项目设计框架。
