Guo Biyu, Liang Yingli, Fu Biru, Luo Jiayi, Zhou Xingchen, Ji Ruifeng, He Xin
School of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Jingji (Guangzhou) Biotechnology Co., Ltd., Guangzhou 510006, China.
Foods. 2024 Aug 8;13(16):2497. doi: 10.3390/foods13162497.
Black ginseng is the processed product of ginseng, and it has been found that the content and types of rare ginsenosides increased after processing. However, there is limited research on the ginsenoside differences between cultivated and forest ginseng before and after processing and among various plant parts. This study investigated the effects of processing on ginsenosides in different parts of cultivated and forest ginseng. After processing, the contents of Re, Rg1, S-Rg3, Rg5, R-Rh1, Rk1, Rk3, and F4 were significantly increased or decreased, the growth age of forest ginseng was not proportional to the content of ginsenosides, and the differences in ginsenoside content in ginseng from different cultivation methods were relatively small. Chemometric analysis identified processing biomarkers showing varying percentage changes in different parts. Network pharmacology predicted the EGFR/PI3K/Akt/mTOR pathway as a potential key pathway for the anti-cancer effect of black ginseng.
黑参是人参的加工产品，并且已发现加工后稀有皂苷的含量和种类有所增加。然而，关于栽培人参和林下参加工前后以及不同植株部位之间的皂苷差异的研究有限。本研究调查了加工对栽培人参和林下参不同部位皂苷的影响。加工后，人参皂苷Re、Rg1、S-Rg3、Rg5、R-Rh1、Rk1、Rk3和F4的含量显著增加或减少，林下参的生长年限与人参皂苷含量不成正比，不同种植方式的人参中人参皂苷含量差异相对较小。化学计量学分析确定了加工生物标志物，其在不同部位显示出不同百分比的变化。网络药理学预测表皮生长因子受体/磷脂酰肌醇-3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白（EGFR/PI3K/Akt/mTOR）通路是黑参抗癌作用的潜在关键通路。
