Rocha Paola Dos Santos da, Orué Sarah Lam, Ferreira Isamara Carvalho, Espindola Priscilla Pereira de Toledo, Rodrigues Maria Victória Benites, Carvalho José Tarcísio Giffoni de, Baldivia Debora da Silva, Leite Daniel Ferreira, Santos Helder Freitas Dos, Oliveira Alex Santos, Campos Jaqueline Ferreira, Dos Santos Edson Lucas, de Picoli Souza Kely
Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, Dourados 79804-970, MS, Brazil.
Pharmaceuticals (Basel). 2024 Aug 13;17(8):1062. doi: 10.3390/ph17081062.
Obesity is a pandemic disease characterized by lipid accumulation, increased proinflammatory cytokines, and reactive oxygen species. It is associated with the development of comorbidities that lead to death. Additionally, drug treatments developed to control obesity are insufficient and have a variety of adverse effects. Thus, the search for new anti-obesity therapies is necessary. is a species from the Brazilian Cerrado that has the potential to treat obesity, as described by the antihyperlipidemic activity of its roots. Therefore, this study aimed to investigate the activity of the aqueous extract of leaves (AECa) on the control of reactive species in vitro, on lipid accumulation in adipocytes and , and on the production of proinflammatory cytokines in adipocytes. The antioxidant capacity of AECa was observed by its action in scavenging DPPH free radical, iron-reducing power, and inhibition of β-carotene bleaching. AECa reduced lipid accumulation in preadipocytes and in . Moreover, AECa reduced the production of the proinflammatory cytokines MCP-1, TNF-α, and IL-6 in adipocytes. In summary, the antioxidant activity and the ability of AECa to reduce the accumulation of lipids and proinflammatory cytokines indicate, for the first time, the anti-obesity potential of leaves.
肥胖是一种大流行性疾病，其特征为脂质蓄积、促炎细胞因子增加以及活性氧物质增多。它与导致死亡的合并症的发展相关。此外，为控制肥胖而研发的药物治疗并不充分，且具有多种不良反应。因此，有必要寻找新的抗肥胖疗法。[植物名称]是一种来自巴西塞拉多的植物，如其根的降血脂活性所述，它具有治疗肥胖的潜力。因此，本研究旨在探讨[植物名称]叶水提取物（AECa）在体外对活性物质的控制、对脂肪细胞和[具体细胞类型]中脂质蓄积以及对脂肪细胞中促炎细胞因子产生的活性。通过其清除DPPH自由基的作用、铁还原能力以及对β - 胡萝卜素漂白的抑制作用来观察AECa的抗氧化能力。AECa减少了前脂肪细胞和[具体细胞类型]中的脂质蓄积。此外，AECa减少了脂肪细胞中促炎细胞因子MCP - 1、TNF - α和IL - 6的产生。总之，AECa的抗氧化活性以及减少脂质和促炎细胞因子蓄积的能力首次表明了[植物名称]叶的抗肥胖潜力。
