A Compound Containing Aldehyde Dehydrogenase Relieves the Effects of Alcohol Consumption and Hangover Symptoms in Healthy Men: An Open-Labeled Comparative Study.

This open-labeled and comparative study aimed to test the efficacy and safety of a fermented rice extract-based substance containing yeast-fermented powder having aldehyde dehydrogenase (KisLip, Pico Entech, Republic of Korea) in healthy male individuals. Healthy male subjects (n = 20) consumed 90 g of alcohol at their first visit. At the second visit, participants consumed 90 g of alcohol or alcohol with a low dose of KISLip (2000 mg, KL-L) and then 90 g of alcohol or alcohol with a high dose of KISLip (3000 mg, KL-H) at the third visit. The efficacy of KISLip depends on the mutational status of important genes related to alcohol metabolism, including alcohol dehydrogenase (), cytochrome P4502E1 ( () and ()), and aldehyde dehydrogenase (). KISLip significantly reduced the highest level (Cmax) of alcohol and overall levels of acetaldehyde compared to the alcohol-only group in a dose-dependent manner. These significant effects of KISLip on alcohol metabolism were observed independent of mutations in the four genes. In addition, hangover symptoms were significantly decreased in the KISLip treated groups. During the study, the participants did not show any adverse events after KISLip intake. This clinical study suggested that supplementation of KISLip had beneficial effects on alcohol metabolism and might ameliorate the severity of hangovers without any adverse events.