Gahn Marie Cicille Ba, Diouf Gorgui, Cissé Ndjibouyé, Ciss Mamadou, Bordier Marion, Ndiaye Mbengué, Bakhoum Mame Thierno, Djiba Mamadou Lamine, Brown Corrie, Faburay Bonto, Fall Assane Gueye, Lo Modou Moustapha
Institut Sénégalais de Recherches Agricoles, Laboratoire National de l'Elevage et de Recherches Vétérinaires (ISRA-LNERV), Dakar-Hann BP 2057, Senegal.
Centre de Coopération Internationale en Recherche Agronomique pour le Developpement (CIRAD), UMR ASTRE, F-34398 Montpellier, France.
Pathogens. 2024 Aug 15;13(8):689. doi: 10.3390/pathogens13080689.
Crimean-Congo hemorrhagic fever (CCHF) and Rift Valley fever (RVF) are among the list of emerging zoonotic diseases that require special attention and priority. RVF is one of the six priority diseases selected by the Senegalese government. Repeated epidemic episodes and sporadic cases of CCHF and RVF in Senegal motivated this study, involving a national cross-sectional serological survey to assess the distribution of the two diseases in this country throughout the small ruminant population. A total of 2127 sera from small ruminants (goat and sheep) were collected in all regions of Senegal. The overall seroprevalence of CCHF and RVF was 14.1% (IC 95%: 12.5-15.5) and 4.4% (95% CI: 3.5-5.3), respectively. The regions of Saint-Louis (38.4%; 95% CI: 30.4-46.2), Kolda (28.3%; 95% CI: 20.9-35.7), Tambacounda (22.2%; 95% CI: 15.8-28.6) and Kédougou (20.9%; 95% CI: 14.4-27.4) were the most affected areas. The risk factors identified during this study show that the age, species and sex of the animals are key factors in determining exposure to these two viruses. This study confirms the active circulation of CCHF in Senegal and provides important and consistent data that can be used to improve the surveillance strategy of a two-in-one health approach to zoonoses.
克里米亚-刚果出血热（CCHF）和裂谷热（RVF）是需要特别关注和优先处理的新兴人畜共患疾病。裂谷热是塞内加尔政府选定的六种重点疾病之一。塞内加尔境内克里米亚-刚果出血热和裂谷热的反复流行以及散发病例促使开展了本研究，该研究涉及一项全国性横断面血清学调查，以评估这两种疾病在该国小反刍动物群体中的分布情况。在塞内加尔所有地区共采集了2127份小反刍动物（山羊和绵羊）的血清。克里米亚-刚果出血热和裂谷热的总体血清阳性率分别为14.1%（95%置信区间：12.5 - 15.5）和4.4%（95%置信区间：3.5 - 5.3）。圣路易地区（38.4%；95%置信区间：30.4 - 46.2）、科尔达地区（28.3%；95%置信区间：20.9 - 35.7）、坦巴昆达地区（22.2%；95%置信区间：15.8 - 28.6）和凯杜古地区（20.9%；95%置信区间：14.4 - 27.4）是受影响最严重的地区。在本研究中确定的风险因素表明，动物的年龄、种类和性别是决定其接触这两种病毒的关键因素。本研究证实了克里米亚-刚果出血热在塞内加尔的活跃传播，并提供了重要且一致的数据，可用于改进人畜共患病一体化健康方法的监测策略。
