Saha Alangkar, Sathish R, Setty Suhas, Maji Abhijit, Saha Jayanta, Chatterjee Abhishek
Department of Oral and Maxillofacial Surgery, IPGMER-SSKM Hospital (Government of W. B), Kolkata, West Bengal, India.
Department of Oral and Maxillofacial Surgery, JSS Dental College and Hospital, Mysore, Karnataka, India.
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1240-S1243. doi: 10.4103/jpbs.jpbs_409_21. Epub 2021 Nov 10.
Healing unbinds a well choreographed array of cellular, physiologic, biochemical, and molecular processes directed toward restoring the integrity and functional capacity of the damaged structures. The rate and degree of healing vary among individuals but is greatest during the first few months or years after tooth loss. Evidence suggests that alveolar bone ridge resorption may be prevented, initially by reconstructive surgical techniques using several materials which are employed at the time of extraction. This droves to the development of bone substitutes materials such as hydroxyapatite, beta tricalcium phosphate (β TCP), and bioactive glasses. These regenerative materials not only act as an osteoconductive scaffold but also interact with the surrounding tissues and impart an osseostimulatory effect.
Twenty adult patients who required bilateral removal of homologous tooth, were informed and described regarding post extraction socket grafting using β TCP and CPS followed by covering with Collagen Membrane. Radiographic densitometry evaluation of postoperative visits of immediate; 1st month; 3rd month; and 6th month using orthopantomograph was done.
The Karl Pearson's Correlation coefficient was used to determine the degree of bone density with adjacent bone preoperatively and postoperatively. The statistical evaluation, CPS was more superior to β TCP, with a difference of 58.75 and value showed more significance (<0.0001).
This article evaluates radiographically quality and quantity of bone formation in the socket, following extraction and bone grafting using Calcium Phosphosilicate (CPS) and β TCP, it is concluded that the two modalities of treatment were efficient in improving the clinical outcome parameters as well as showed comparable regenerative effects when used in the treatment of "socket grafting" while between them CPS more superior to β TCP biomaterials by Osteogenic properties.
愈合过程会启动一系列精心编排的细胞、生理、生化和分子过程，旨在恢复受损结构的完整性和功能能力。愈合的速度和程度因人而异，但在牙齿缺失后的最初几个月或几年内最为显著。有证据表明，牙槽骨嵴吸收最初可通过拔牙时使用多种材料的重建手术技术来预防。这推动了骨替代材料的发展，如羟基磷灰石、β-磷酸三钙（β TCP）和生物活性玻璃。这些再生材料不仅作为骨传导支架，还与周围组织相互作用并产生骨刺激作用。
20名需要双侧拔除同源牙的成年患者，被告知并描述了拔牙后牙槽窝使用β TCP和磷酸硅钙（CPS）移植，随后覆盖胶原膜的情况。使用全景X线断层摄影术对术后即刻、第1个月、第3个月和第6个月的随访进行影像学骨密度评估。
采用卡尔·皮尔逊相关系数来确定术前和术后与相邻骨的骨密度程度。统计学评估显示，CPS比β TCP更具优势，差异为58.75，且P值显示出更显著的差异（<0.0001）。
本文通过影像学评估了拔牙及使用磷酸硅钙（CPS）和β TCP进行骨移植后牙槽窝内骨形成的质量和数量，得出结论：这两种治疗方式在改善临床结果参数方面均有效，并且在用于“牙槽窝移植”治疗时显示出可比的再生效果，而在它们之间，CPS在成骨特性方面比β TCP生物材料更具优势。
