人D小基因可能参与κ轻链的第一个互补决定区。
Possible involvement of human D minigenes in the first complementarity-determining region of kappa light chains.
作者信息
Chen P P, Kabat E A, Wu T T, Fong S, Carson D A
出版信息
Proc Natl Acad Sci U S A. 1985 Apr;82(7):2125-7. doi: 10.1073/pnas.82.7.2125.
Abstract
The nucleotide sequences of the complementary strands of two human diversity region (D) minigenes, D2 and D4, show stretches of homology with two human variable region kappa chain (V kappa) genes, NG9 and HK101, respectively, in the first complementarity-determining region. In one V kappa sequence, the homology includes the 5' flanking region of D minigenes, which may comprise a recombinase recognition signal. It is thus conceivable that gene conversions involving D minigenes may contribute to V kappa diversity.
摘要
两个人类多样性区域（D）小基因D2和D4的互补链的核苷酸序列，在第一个互补决定区分别与两个人类可变区κ链（Vκ）基因NG9和HK101呈现出同源性片段。在一个Vκ序列中，这种同源性包括D小基因的5'侧翼区，该区可能包含一个重组酶识别信号。因此可以想象，涉及D小基因的基因转换可能对Vκ多样性有贡献。
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2
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3
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4
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