Department of Endocrinology, the Second Medical Centre & National Clinical Research Centre for Geriatric Disease, Chinese PLA General Hospital, Beijing, China.
Department of Nephrology, the Second Medical Centre & National Clinical Research Centre for Geriatric Disease, Chinese PLA General Hospital, Beijing, China.
Asia Pac J Clin Nutr. 2024 Dec;33(4):569-580. doi: 10.6133/apjcn.202412_33(4).0012.
Malnutrition is associated with a higher risk of osteoporosis. We aim to assess the relationship between serum albumin with geriatric nutritional risk index and osteopenia in Chinese elderly men.
This is a nested case-control study from a prospective cohort enrolled 1109 individuals who were followed for seven years. Demographic data, medical history, signs and symptoms, and laboratory parameters were collected and analysed. Nutritional status and Geriatric Nutritional Risk Index (GNRI) were assessed. The nutrition-related indexes predictive value for osteopenia development was analyzed through multivariate Cox regression analysis and by creating a receiver operating characteristic curve (ROC), calculating the area under the curve (AUC). Kaplan-Meier (K-M) method was further used to find the nutritional status level in the elderly men.
The ALB and GNRI correlated with the risk of osteopenia in Chinese elderly men. After adjusting for all covariates, people with higher ALB level (HR: 0.821; 95% CI: 0.790-0.852) and higher GNRI score (HR: 0.889; 95% CI: 0.869-0.908) had a smaller risk of osteopenia. ROC analysis showed that the AUC for ALB was 0.729 (p<0.05) and for the GNRI score was 0.731 (p<0.05). K-M curve indicated a significant difference in ALB level (p<0.001) and GNRI score (p<0.001) in the respective subgroups.
This study found that lower ALB level and lower GNRI score are associated with a higher prevalence of osteopenia among elderly men in China.
营养不良与骨质疏松症的风险增加有关。我们旨在评估中国老年男性血清白蛋白与老年营养风险指数（GNRI）与骨量减少之间的关系。
这是一项从前瞻性队列中嵌套的病例对照研究，共纳入了 1109 名随访 7 年的个体。收集和分析了人口统计学数据、病史、体征和症状以及实验室参数。评估了营养状况和老年营养风险指数（GNRI）。通过多变量 Cox 回归分析和创建接收器操作特征曲线（ROC），计算曲线下面积（AUC），分析了与骨量减少发展相关的营养相关指标的预测价值。进一步使用 Kaplan-Meier（K-M）方法寻找老年男性的营养状况水平。
ALB 和 GNRI 与中国老年男性的骨质疏松症风险相关。在调整了所有协变量后，ALB 水平较高的人群（HR：0.821；95%CI：0.790-0.852）和 GNRI 评分较高的人群（HR：0.889；95%CI：0.869-0.908）发生骨质疏松症的风险较小。ROC 分析显示，ALB 的 AUC 为 0.729（p<0.05），GNRI 评分的 AUC 为 0.731（p<0.05）。K-M 曲线表明，在相应的亚组中，ALB 水平（p<0.001）和 GNRI 评分（p<0.001）存在显著差异。
本研究发现，中国老年男性中 ALB 水平较低和 GNRI 评分较低与骨量减少的患病率较高相关。
