Long Xiya, Zeng Jinsheng
Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, Guangzhou, China.
Stroke Vasc Neurol. 2025 Apr 29;10(2):e003504. doi: 10.1136/svn-2024-003504.
Numerous seemingly promising cerebroprotectants previously validated in rodents almost all have failed in stroke clinical trials. The failure of clinical translation strikes an essential need to employ more ideal animal models in stroke research. Compared with the most commonly used rodent models of stroke, non-human primates (NHPs) are far more comparable to humans regarding brain anatomy, functionality and pathological features. The aim of this perspective was to summarise the advantages of NHPs stroke models over rodents, discuss the current limitations of NHPs models, and cast an outlook on the future development of NHPs in stroke preclinical research.
许多先前在啮齿动物中得到验证的看似有前景的脑保护剂，几乎都在中风临床试验中失败了。临床转化的失败凸显了在中风研究中采用更理想动物模型的迫切需求。与最常用的啮齿动物中风模型相比，非人灵长类动物（NHPs）在脑解剖结构、功能和病理特征方面与人类更为相似。这篇观点文章的目的是总结NHPs中风模型相对于啮齿动物模型的优势，讨论NHPs模型目前存在的局限性，并展望NHPs在中风临床前研究中的未来发展。
