Results of combined amphotericin B-5-fluorcytosine therapy for prosthetic knee joint infected with Candida parapsilosis.

A prosthetic knee joint became infected with Candida parapsilosis, apparently introduced by arthrocentesis. The infection was quite indolent, present for several months before treatment. Although the joint fluid contained antibiotic concentrations in excess of the organism's minimum inhibitory concentration, medical therapy failed, and cure required removing the prosthesis and fusion of the knee.