Alliance for Medical Research in Africa, Department of Medical Physiology, Cheikh Anta Diop University, Dakar, Senegal.
Department of Cardiology, Hôpital Européen Georges Pompidou, 20 Rue Leblanc, 75015, Paris, France.
Sci Rep. 2024 Aug 29;14(1):20052. doi: 10.1038/s41598-024-70806-8.
Heart rate, a measure of the frequency of the cardiac cycle, reflects the health of the cardiovascular system, metabolic rate, and activity of the autonomic nervous system. Whether changes in resting heart rate are related to lifespan has not yet been explored to our best knowledge. In this study, we examined the association between resting heart rate and lifespan using linear regression in the Paris Prospective Study I, the Whitehall I Study, and the Framingham Heart Study. We used Cox proportional hazards regression to relate changes in heart rate over years to mortality risk. We observed a statistically significant association between increases in resting heart rate over a 5-year period and risk of mortality in the Paris Prospective Study I (HR mortality per 10 bpm increase over time: 1.20; 95% CI: 1.13 to 1.27) and over an 8-year period in the Framingham Heart Study (HR: 1.13; 95% CI: 1.07 to 1.19 for men and HR: 1.09; 95% CI: 1.04 to 1.15 for women), after adjusting for classical risk factors and resting heart rate. Our study shows that men and women who increase their resting heart rate over time increase their risk of mortality.
心率是心脏周期频率的衡量标准，反映了心血管系统、代谢率和自主神经系统的活动的健康状况。据我们所知，静息心率的变化是否与寿命有关，尚未得到充分探讨。在这项研究中，我们使用线性回归分析了巴黎前瞻性研究 I、白厅 I 研究和弗雷明汉心脏研究中静息心率与寿命之间的关系。我们使用 Cox 比例风险回归分析了多年来心率变化与死亡率风险之间的关系。我们观察到，在巴黎前瞻性研究 I 中，静息心率在 5 年内增加与死亡率风险呈统计学显著相关（每增加 10 bpm 的死亡率 HR：1.20；95%CI：1.13 至 1.27），在弗雷明汉心脏研究中，静息心率在 8 年内增加与死亡率风险呈统计学显著相关（男性 HR：1.13；95%CI：1.07 至 1.19，女性 HR：1.09；95%CI：1.04 至 1.15），调整了经典风险因素和静息心率后。我们的研究表明，随着时间的推移，静息心率增加的男性和女性的死亡率风险增加。
