• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

普遍的生物尺度与死亡率

Universal biological scaling and mortality.

机构信息

Raymond and Beverly Sackler Faculty of Exact Sciences, School of Physics and Astronomy, Tel Aviv University, Ramat Aviv, Israel.

出版信息

Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12453-7. doi: 10.1073/pnas.91.26.12453.

DOI:10.1073/pnas.91.26.12453
PMID:7809058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC45456/
Abstract

Universal scaling relations for basal metabolism, heart rate, and life-span are presented in a physically transparent form with no adjustable parameters. Their accuracy is a few percent for animals ranging from invertebrates to mammals. They suggest that natural death is related to irreparable molecular damage to specific cells or molecules.

摘要

基础代谢、心率和寿命的通用标度关系以一种物理上透明的形式呈现,且没有可调整的参数。对于从无脊椎动物到哺乳动物的各类动物而言,它们的准确度约为百分之几。这些关系表明,自然死亡与特定细胞或分子的不可修复的分子损伤有关。

相似文献

1
Universal biological scaling and mortality.普遍的生物尺度与死亡率
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12453-7. doi: 10.1073/pnas.91.26.12453.
2
Energy metabolism, brain size and longevity in mammals.哺乳动物的能量代谢、脑容量与寿命
Q Rev Biol. 1983 Dec;58(4):495-512. doi: 10.1086/413544.
3
The linear allometric relationship between total metabolic energy per life span and body mass of mammals.哺乳动物每一生存期的总代谢能量与体重之间的线性异速生长关系。
Biosystems. 2007 Jul-Aug;90(1):224-33. doi: 10.1016/j.biosystems.2006.08.006. Epub 2006 Aug 23.
4
Genetic relation of life span to metabolic rate for inbred mouse strains and their hybrids.近交系小鼠及其杂种的寿命与代谢率的遗传关系。
Fed Proc. 1979 Feb;38(2):184-8.
5
Allometric cascade as a unifying principle of body mass effects on metabolism.异速生长级联作为体重对新陈代谢影响的统一原则。
Nature. 2002 May 9;417(6885):166-70. doi: 10.1038/417166a.
6
Metabolism and aging: effects of cold exposure on metabolic rate, body composition, and longevity in mice.新陈代谢与衰老:寒冷暴露对小鼠代谢率、身体组成及寿命的影响
Physiol Biochem Zool. 2009 Jul-Aug;82(4):314-24. doi: 10.1086/589727.
7
On the complex relationship between energy expenditure and longevity: Reconciling the contradictory empirical results with a simple theoretical model.关于能量消耗与寿命之间的复杂关系:用一个简单的理论模型调和相互矛盾的经验结果。
Mech Ageing Dev. 2015 Jul;149:50-64. doi: 10.1016/j.mad.2015.06.003. Epub 2015 Jun 15.
8
Ontogenetic phase shifts in metabolism in a flounder Paralichthys olivaceus.牙鲆(Paralichthys olivaceus)新陈代谢的个体发生阶段变化
Sci Rep. 2014 Nov 20;4:7135. doi: 10.1038/srep07135.
9
NUMT ("new mighty") hypothesis of longevity.长寿的 NUMT(“新强大”)假说。
Rejuvenation Res. 2010 Apr-Jun;13(2-3):152-5. doi: 10.1089/rej.2009.0974.
10
Allometric scaling of the maximum metabolic rate of mammals: oxygen transport from the lungs to the heart is a limiting step.哺乳动物最大代谢率的异速生长缩放:氧气从肺部到心脏的运输是一个限制步骤。
Theor Biol Med Model. 2005 Aug 11;2:31. doi: 10.1186/1742-4682-2-31.

引用本文的文献

1
Association between change in heart rate over years and life span in the Paris Prospective 1, the Whitehall 1, and Framingham studies.多年心率变化与巴黎前瞻性研究 1、白厅研究 1 和弗雷明汉研究中寿命的关系。
Sci Rep. 2024 Aug 29;14(1):20052. doi: 10.1038/s41598-024-70806-8.
2
Peto's "Paradox" and Six Degrees of Cancer Prevalence.佩托悖论与癌症患病率的六度关联
Cells. 2024 Jan 21;13(2):197. doi: 10.3390/cells13020197.
3
Universal relation for life-span energy consumption in living organisms: Insights for the origin of aging.生物体寿命能量消耗的普遍关系:衰老起源的新见解。
Sci Rep. 2022 Feb 21;12(1):2407. doi: 10.1038/s41598-022-06390-6.
4
Resting Heart Rate as a Predictor of Cancer Mortality: A Systematic Review and Meta-Analysis.静息心率作为癌症死亡率的预测指标:一项系统评价与荟萃分析
J Clin Med. 2021 Mar 25;10(7):1354. doi: 10.3390/jcm10071354.
5
Perspective: Why Exercise Is Good and Its Lack Bad for Everything.观点:为何运动有益而缺乏运动对一切都有害。
Am J Lifestyle Med. 2018 Jun 11;13(3):269-274. doi: 10.1177/1559827618778236. eCollection 2019 May-Jun.
6
Ivabradine has a neutral effect on mortality in randomized controlled trials.在随机对照试验中,伊伐布雷定对死亡率具有中性影响。
Medicine (Baltimore). 2017 Oct;96(40):e8067. doi: 10.1097/MD.0000000000008067.
7
Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.鉴定与静息心率相关的基因组位点,并与全因死亡率共享遗传预测因子。
Nat Genet. 2016 Dec;48(12):1557-1563. doi: 10.1038/ng.3708. Epub 2016 Oct 31.
8
Toward a systems biology framework for understanding aging and health span.迈向用于理解衰老和健康寿命的系统生物学框架。
J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):205-8. doi: 10.1093/gerona/gln066. Epub 2009 Feb 17.
9
The role of heart rate in the development of cardiovascular disease.心率在心血管疾病发展中的作用。
Clin Res Cardiol. 2007 Sep;96(9):585-92. doi: 10.1007/s00392-007-0537-5. Epub 2007 Jun 27.
10
Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size.哺乳动物骨骼肌缩短速度的缩放比例,其体型差异达10万倍。
Pflugers Arch. 2006 May;452(2):222-30. doi: 10.1007/s00424-005-0017-6. Epub 2005 Dec 7.

本文引用的文献

1
Similarity principles for the biology of pelagic animals.海洋动物生物学的相似性原理。
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3540-2. doi: 10.1073/pnas.80.11.3540.
2
Optimality, mutation and the evolution of ageing.最优性、突变与衰老的进化
Nature. 1993 Mar 25;362(6418):305-11. doi: 10.1038/362305a0.
3
A truncated erythropoietin receptor and cell death: a reanalysis.截短型促红细胞生成素受体与细胞死亡:重新分析
Science. 1994 Apr 22;264(5158):588-9. doi: 10.1126/science.8160019.
4
Energy metabolism and body size. I. Is the 0.75 mass exponent of Kleiber's equation a statistical artifact?能量代谢与体型。I. 克莱伯方程中0.75的质量指数是统计假象吗?
Respir Physiol. 1982 Apr;48(1):1-12. doi: 10.1016/0034-5687(82)90046-9.
5
The 3/4 mass exponent for energy metabolism is not a statistical artifact.能量代谢的3/4质量指数并非统计假象。
Respir Physiol. 1983 May;52(2):149-63. doi: 10.1016/0034-5687(83)90002-6.
6
Size and shape in biology.生物学中的大小与形状。
Science. 1973 Mar 23;179(4079):1201-4. doi: 10.1126/science.179.4079.1201.
7
A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells.一种截短的促红细胞生成素受体,无法阻止红系细胞的程序性细胞死亡。
Science. 1992 Aug 21;257(5073):1138-41. doi: 10.1126/science.257.5073.1138.
8
Letter: Longevity in vertebrates is proportional to relative brain weight.信件:脊椎动物的寿命与相对脑重量成正比。
Fed Proc. 1975 Nov;34(12):2102-3.