Blumberg N, Agarwal M M, Chuang C
Br Med J (Clin Res Ed). 1985 Apr 6;290(6474):1037-9. doi: 10.1136/bmj.290.6474.1037.
Data suggest that blood transfusion can cause immunosuppression. The incidence of recurrence of tumours was examined retrospectively in patients who had undergone potentially curative operations for cancer of the colon during 1970-81. Tumours recurred in six of 68 patients (9%) who had not been given transfusions and in 56 of 129 patients (43%) who had (p much less than 0.0001). Transfusion was also found to be significantly associated with the time to recurrence after adjustment for other baseline prognostic factors (p less than 0.05). Perioperative transfusion may be a significant risk factor in the prognosis of cancer of the colon. Whether this association is causal is unknown.
数据表明输血可能导致免疫抑制。对1970年至1981年间接受过结肠癌根治性手术的患者肿瘤复发率进行了回顾性研究。未接受输血的68例患者中有6例(9%)肿瘤复发,接受输血的129例患者中有56例(43%)肿瘤复发(p远小于0.0001)。在对其他基线预后因素进行调整后,还发现输血与复发时间显著相关(p小于0.05)。围手术期输血可能是结肠癌预后的一个重要危险因素。这种关联是否具有因果关系尚不清楚。