Power K G, Jerrom D W, Simpson R J, Mitchell M
Br Med J (Clin Res Ed). 1985 Apr 27;290(6477):1246-8. doi: 10.1136/bmj.290.6477.1246.
A group of patients suffering from anxiety, as assessed by general practitioners and psychologists using research criteria for generalised anxiety, were treated with either diazepam or placebo double blind for six weeks. This active treatment period was preceded by a one week single blind placebo "wash in" period and followed by a two week single blind placebo "wash out" period. The results suggest that diazepam can produce rebound anxiety and withdrawal symptoms when used in moderate doses and for what has previously been regarded as a safe length of time. If replicated these results have implications for the therapeutic use of benzodiazepines.
一组经全科医生和心理学家根据广泛性焦虑研究标准评估为患有焦虑症的患者，采用双盲法，分别接受为期六周的地西泮或安慰剂治疗。在这个积极治疗期之前，有一个为期一周的单盲安慰剂“导入”期，之后是一个为期两周的单盲安慰剂“洗脱”期。结果表明，地西泮在中等剂量使用且使用时间为先前认为的安全时长时，会产生反弹性焦虑和戒断症状。如果这些结果得到重复验证，将对苯二氮䓬类药物的治疗应用产生影响。
