Winokur A, Rickels K, Greenblatt D J, Snyder P J, Schatz N J
Arch Gen Psychiatry. 1980 Jan;37(1):101-5. doi: 10.1001/archpsyc.1980.01780140103012.
Symptoms of diazepam withdrawal developed in a young man who had been taking diazepam in dosages of 15 to 25 mg/day during a six-year period. This was verified in a study conducted under placebo-controlled, double blind conditions, with plasma levels of diazepam and its major metabolite, desmethyldiazepam, monitored throughout the course of the study. Severe symptoms of physiological withdrawal were observed within two days of replacement of diazepam with placebo capsules. The patient recovered promptly on reinstitution of diazepam administration, and relapsed during a second withdrawal phase. During an additional two week-period of placebo administration, the patient's condition first worsened, then gradually improved. Examination of plasma levels of diazepam and desmethyldiazepam indicated no obvious pharmacokinetic abnormalities. Thus, with long-term administration of diszepam, even in therapeutically accepted doses, withdrawal reactions can be encountered on abrupt termination.
一名年轻男子在六年时间里每天服用15至25毫克地西泮，出现了地西泮戒断症状。这在一项安慰剂对照、双盲条件下进行的研究中得到了证实，在整个研究过程中监测了地西泮及其主要代谢产物去甲基地西泮的血浆水平。在用地安慰剂胶囊替代地西泮后的两天内观察到了严重的生理戒断症状。重新给予地西泮后，患者迅速康复，并在第二个戒断阶段复发。在额外两周的安慰剂给药期间，患者的病情先是恶化，然后逐渐改善。对地西泮和去甲基地西泮的血浆水平检查表明没有明显的药代动力学异常。因此，长期服用地西泮，即使是在治疗上可接受的剂量，突然停药时也可能会出现戒断反应。
