Yamashita F, Hayashi M
Environ Health Perspect. 1985 Feb;59:41-5. doi: 10.1289/ehp.59-1568075.
Pregnant mothers with yusho in Fukuoka, Nagasaki and Kochi Prefectures delivered babies with a peculiar clinical manifestation which will be called fetal PCB syndrome (FPS). The birth rate incidences were 3.6% (Fukuoka Prefecture), 4% (Nagasaki Prefecture), 2.9% (Kochi Prefecture) and 3.9% (total). The manifestations consisted of dark brown pigmentation of the skin and the mucous membrane, gingival hyperplasia, exophthalmic edematous eye, dentition at birth, abnormal calcification of the skull as demonstrated by X-ray, rocker bottom heel and high incidence of light for date (low birth weight) babies. We suggest that there may be a possible alteration in calcium metabolism in these babies, related to the fragile egg shells observed in PCB-contaminated birds and to the female hormone-enhancing effect of PCB. The high incidence of low birth weight among these newborns and two other similar studies indicated that PCBs suppress fetal growth.
福冈、长崎和高知县患有油症的孕妇分娩出的婴儿具有一种特殊的临床表现，将其称为胎儿多氯联苯综合征（FPS）。出生率分别为3.6%（福冈县）、4%（长崎县）、2.9%（高知县）以及3.9%（总计）。这些表现包括皮肤和黏膜的深褐色色素沉着、牙龈增生、眼球突出性水肿眼、出生时出牙、X射线显示的颅骨异常钙化、摇椅底足跟以及过期产儿（低体重）的高发生率。我们认为这些婴儿的钙代谢可能存在改变，这与多氯联苯污染鸟类中观察到的脆弱蛋壳以及多氯联苯的雌激素增强作用有关。这些新生儿中低体重的高发生率以及另外两项类似研究表明，多氯联苯会抑制胎儿生长。
